Enhertu 100mg Powder For Injection

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Prescription Required

Orders placed now will be queued. A doctor will contact you on the next working day for approval.

Overview

Enhertu 100mg Powder For Injection contains trastuzumab deruxtecan, a HER2-targeted antibody-drug conjugate given by intravenous infusion under oncology specialist supervision, used to treat HER2-positive and certain HER2-low breast cancers, as well as HER2-positive gastric cancer.

It combines an antibody that specifically recognises the HER2 protein on cancer cells with a potent chemotherapy payload attached to it. Once the antibody binds to HER2 on a cancer cell, the cell absorbs the whole complex and releases the chemotherapy component inside the cell, destroying it while limiting exposure to healthy cells.

How it Works

The antibody portion of Enhertu binds specifically to HER2 protein on the surface of cancer cells. The cancer cell then internalises the whole complex, releasing the attached cytotoxic (cell-killing) chemotherapy component inside the cell, which disrupts DNA and leads to cancer cell death while reducing exposure of normal cells.

Directions for Use

This medicine is prepared and administered only by trained healthcare professionals as an IV infusion, with close monitoring during and after the infusion, particularly for the first dose.

Dosage

Dosing is calculated by the treating oncologist based on body weight and the specific cancer being treated, then given as a timed intravenous infusion every three weeks in a hospital or specialist infusion setting.

Shelf Life

Refer to the expiry date printed on the packaging; this medicine is stored and handled only by healthcare facilities.

Storage Instructions

Stored under controlled, refrigerated conditions by the pharmacy or hospital as specified by the manufacturer; not intended for home storage.

Side Effects

  • Nausea, vomiting, and fatigue
  • Hair loss (alopecia)
  • Low blood cell counts, including neutropenia and anaemia
  • Interstitial lung disease or pneumonitis (a boxed-warning risk – report new cough, breathlessness, or fever immediately)
  • Reduced heart pumping function (decreased left ventricular ejection fraction) – monitored with periodic heart scans

Contraindications

  • Known hypersensitivity to trastuzumab deruxtecan or any ingredient in the formulation
  • Pregnancy, due to potential serious harm to the developing baby
  • Pre-existing interstitial lung disease requiring oxygen therapy, unless specifically assessed by the oncology team

Drug / Food Interactions

  • Other medicines affecting heart or lung function require careful review by the oncology team alongside this medicine.
  • Live vaccines are generally avoided during treatment.
  • Inform your oncology team of all medicines and supplements you are taking before each cycle.

Quick Tips

  • Contact your care team immediately if you develop new or worsening cough, breathlessness, or fever, as this can signal a rare but serious lung side effect.
  • Attend all scheduled heart function scans (echocardiograms) during treatment.
  • Report any signs of infection promptly, as low blood counts can increase infection risk.
  • Discuss fertility and contraception with your oncology team before starting treatment.

Frequently Asked Questions

What is Enhertu 100mg used for?

It is used to treat HER2-positive and certain HER2-low breast cancers, as well as HER2-positive gastric cancer, as decided by an oncology specialist.

What is an antibody-drug conjugate?

It is a targeted medicine that combines an antibody that finds cancer cells with a chemotherapy component, delivering the chemotherapy more directly to cancer cells expressing HER2.

Do I need a HER2 test before starting this medicine?

Yes, HER2 testing on your tumour tissue determines whether this medicine is appropriate for your specific cancer.

What lung symptoms need urgent attention?

New or worsening cough, breathlessness, or fever should be reported immediately, as this medicine carries a boxed warning for a rare but serious lung condition.

Will my heart function be monitored?

Yes, periodic heart scans (echocardiograms) are used to monitor for reduced heart pumping function during treatment.

Is this medicine given as a tablet?

No, it is given only as an intravenous infusion, usually every three weeks, administered by healthcare professionals.

Will I lose my hair during treatment?

Hair loss is a common side effect of this medicine; your oncology team can advise on what to expect and support options.

Can I buy Enhertu 100mg Powder For Injection from DoctorOnCall?

Yes, Enhertu 100mg Powder For Injection is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.

Is the medication provided by DoctorOnCall genuine and safe to use?

DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Enhertu 100mg Powder For Injection according to your doctor’s instructions and the information provided with the product.

What payment methods does DoctorOnCall accept?

We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.

Does DoctorOnCall provide an installment payment plan for Enhertu 100mg Powder For Injection?

DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.

Is delivery free, and how much does shipping for Enhertu 100mg Powder For Injection cost?

Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.

How long does delivery take for Enhertu 100mg Powder For Injection?

Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.

What is DoctorOnCall’s shipping, return, or cancellation policy for Enhertu 100mg Powder For Injection?

Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.

Ingredients / Active Ingredients

  • Trastuzumab deruxtecan 100mg (powder for reconstitution)

Medical Review

Written by:

Dr. Chong Zhan Pong

Doctor of Medicine (MD), International Medical University (IMU)

Reviewed by:

Dr. Mohd Izzat Amir Bin Awang

Doctor of Medicine (MD), University of Mansoura - Manchester

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