Epilim Chrono 500mg Tablet

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Manufacturer Sanofi
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Epilim Chrono 500mg Tablet contains Sodium valproate 500mg and is available as a tablet. It is classified as a prescription medicine and may only be obtained with a valid prescription from a registered medical practitioner.

Only product, safety and handling information is published here. Anything beyond that is explained to you directly by your doctor or pharmacist as part of your consultation.

DoctorOnCall is a licensed online pharmacy. Orders for Epilim Chrono 500mg Tablet are processed only after a doctor has assessed your suitability and issued a prescription, and every order is checked by a registered pharmacist before it is sent out.

Directions for Use

Swallow the tablet whole with water. Do not crush or chew it, as this destroys the extended-release effect. Can be taken with or without food, at consistent times each day.

Dosage

The dose of Epilim Chrono 500mg Tablet is individualised based on your seizure type, response to treatment, and blood valproate level monitoring. Treatment is usually started at a lower dose and increased gradually by your doctor. Given the careful balance needed between seizure control and the risks of this medicine (including in pregnancy), never start, stop, or adjust your dose without your specialist’s guidance.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Drowsiness or dizziness
  • Nausea or vomiting
  • Weight gain
  • Tremors (shaking hands)
  • Hair thinning or loss
  • Changes in liver function tests
  • Stomach pain or indigestion

Contraindications

  • Known hypersensitivity to sodium valproate or any ingredient in this product
  • Active liver disease or a history of severe hepatic dysfunction
  • Known urea cycle disorders
  • Porphyria
  • Pregnancy, or the possibility of becoming pregnant, without an effective pregnancy prevention programme in place, due to the high risk of serious birth defects and developmental problems (foetal valproate syndrome) – unless no other suitable treatment is available, as assessed by a specialist

Drug / Food Interactions

  • Other antiepileptics, such as lamotrigine, phenytoin, or carbamazepine, can have significant level interactions with valproate, requiring dose adjustment and monitoring
  • Carbapenem antibiotics (e.g. meropenem, imipenem) can significantly reduce valproate blood levels, risking breakthrough seizures, and are generally avoided together
  • Aspirin and other highly protein-bound medicines may increase free valproate levels in the blood
  • Alcohol can increase sedation and add to the risk of liver-related side effects, and should be avoided or limited

Quick Tips

  • Never stop or start this medicine, or change your dose, without your specialist’s guidance
  • Attend all scheduled blood tests (liver function, blood counts, and valproate levels) as advised
  • Women and girls of childbearing potential must discuss the pregnancy prevention programme and the risks of valproate in pregnancy with their doctor before, and while, taking this medicine
  • Report unexplained vomiting, severe tiredness, loss of appetite, or abdominal pain to your doctor immediately
  • Avoid alcohol while taking this medicine
  • Carry a valproate alert card or similar documentation if provided by your doctor or pharmacist

Ingredients / Active Ingredients

  • Sodium valproate 500mg

Safety Advice

Pregnancy

Not Advisable

Use during pregnancy is generally not recommended unless absolutely necessary.

Breastfeeding

Limited Data

Limited data on excretion in breast milk. Consult a doctor before use.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Limited Data

Limited data available in liver disease patients.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandSanofi-Aventis
ManufacturerSanofi
ClassificationPrescription medicine
Ingredients / Active IngredientsSodium Valproate
Pack Size30s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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