Estiva 600mg Tablet + Tenohope-E Tablet

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Manufacturer Hetero Labs
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Estiva 600mg Tablet + Tenohope-E Tablet contains Estiva 600mg Tablet: Efavirenz 600mg and Tenohope-E Tablet: Tenofovir disoproxil fumarate 300mg + Emtricitabine 200mg and is available as a tablet. It is classified as a prescription medicine and may only be obtained with a valid prescription from a registered medical practitioner.

Only product, safety and handling information is published here. Anything beyond that is explained to you directly by your doctor or pharmacist as part of your consultation.

DoctorOnCall is a licensed online pharmacy. Orders for Estiva 600mg Tablet + Tenohope-E Tablet are processed only after a doctor has assessed your suitability and issued a prescription, and every order is checked by a registered pharmacist before it is sent out.

Directions for Use

Take one tablet of each medicine together, once daily, at approximately the same time each day, ideally at bedtime. Swallow the tablets whole with water. Taking efavirenz on an empty stomach or with a light snack, rather than a high-fat meal, may reduce the intensity of central nervous system side effects such as dizziness or vivid dreams. If a dose is missed, take it as soon as remembered unless it is close to the time of the next dose, in which case the missed dose should be skipped – never take a double dose, and contact your HIV care team if doses are missed regularly.

Dosage

The usual dose is one Estiva 600mg tablet and one Tenohope-E tablet taken together, once daily, preferably at bedtime on an empty stomach or with a light, low-fat snack, which may help reduce nervous system side effects associated with efavirenz. The prescribing doctor determines suitability, any dose adjustments (for example, in patients with reduced kidney function), and the overall duration of treatment, which for HIV is typically lifelong – patients must never stop or skip doses without medical guidance, as doing so risks the virus developing resistance to these medicines.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Dizziness, vivid dreams, or difficulty sleeping, particularly in the first weeks of efavirenz treatment
  • Skin rash
  • Nausea, diarrhoea, or fatigue
  • Changes in kidney function markers, particularly with long-term tenofovir use
  • Changes in mood, including depression, in some patients taking efavirenz

Contraindications

  • Known hypersensitivity to efavirenz, tenofovir disoproxil fumarate, emtricitabine, or any component of the formulation
  • Severe kidney impairment (specific dose adjustment or an alternative regimen may be required)
  • Concurrent use with certain other medicines that interact significantly with efavirenz, as advised by the HIV specialist
  • Not recommended during pregnancy or breastfeeding unless specifically advised by the treating doctor, given the need to weigh maternal and infant risks individually

Drug / Food Interactions

  • Efavirenz interacts with many other medicines, including some other antiretrovirals, anticonvulsants, and certain antifungals – always inform your HIV specialist before starting any new medicine, including herbal products
  • St John’s Wort must not be used with efavirenz, as it can significantly reduce efavirenz levels and risk treatment failure
  • Combining with other medicines that affect kidney function may increase the risk of kidney-related side effects associated with tenofovir
  • High-fat meals can increase efavirenz absorption and may worsen central nervous system side effects – a light or empty-stomach dosing approach is generally preferred

Quick Tips

  • Take both tablets together at the same time every day, ideally at bedtime, to support the high adherence needed for effective treatment
  • Attend all scheduled clinic visits and blood tests to monitor your viral load, CD4 count, kidney function, and liver function
  • Tell your HIV care team about every other medicine, supplement, or herbal product you are taking or plan to start
  • Never stop or interrupt treatment without speaking to your HIV care team first, as doing so can lead to drug resistance

Ingredients / Active Ingredients

  • Estiva 600mg Tablet: Efavirenz 600mg
  • Tenohope-E Tablet: Tenofovir disoproxil fumarate 300mg + Emtricitabine 200mg

Frequently Asked Questions

Product Specifications

BrandHetero Labs
ManufacturerHetero Labs
ClassificationPrescription medicine
Pack Size30s+30s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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