Genotropin 12mg Powder and Solvent Solution for Injection

Genotropin 12mg Powder and Solvent Solution for Injection contains somatropin 12mg, a recombinant human growth hormone given by subcutaneous injection under the supervision of a specialist endocrinologist. It is used to treat growth hormone deficiency in children and adults, and certain other specialist-diagnosed growth disorders.

Somatropin is structurally identical to the growth hormone naturally produced by the pituitary gland. It works by stimulating growth in children with growth hormone deficiency and by supporting normal metabolic functions related to growth hormone in adults, including effects on bone density, muscle mass, and fat metabolism.

Somatropin binds to growth hormone receptors in the liver and other tissues, stimulating the production of insulin-like growth factor 1 (IGF-1), which drives bone and tissue growth in children and supports metabolic processes such as protein synthesis, fat breakdown, and bone density maintenance in both children and adults.

Genotropin 12mg Powder and Solvent Solution for Injection is a powder and solvent for reconstitution into a solution for injection, given by subcutaneous (under the skin) injection using the specific pen or device supplied with the product, as taught to you by your endocrinologist or trained nurse. Rotate injection sites as instructed to reduce the risk of local skin changes, and never share your injection pen or needles with anyone else.

Genotropin 12mg Powder and Solvent Solution for Injection dosing is entirely individualised by your specialist endocrinologist, based on your age, body weight, diagnosis, and response to treatment, with periodic adjustment based on growth response, IGF-1 levels, and other monitoring results. Never adjust your dose without specific guidance from your specialist – there is no standard fixed dose for every patient.

Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

Store in a refrigerator (2-8°C) before reconstitution. Do not freeze. Storage requirements after reconstitution vary by specific pen or cartridge device, so always follow the specific storage instructions provided with your product and the counselling given by your pharmacist or endocrinology team, rather than assuming a general storage duration.

• Injection site reactions (redness, swelling, pain, or itching)
• Headache
• Joint pain or muscle aches
• Mild swelling of the hands or feet (fluid retention), particularly in adults
• Serious: signs of high blood sugar (excessive thirst, frequent urination, unusual tiredness), severe headache with vision changes or vomiting (possible sign of raised pressure in the brain), or a severe allergic reaction (swelling, difficulty breathing) require immediate medical attention

• Known hypersensitivity to somatropin or any ingredient in this product
• Evidence of active tumour growth – active malignancy should be resolved or specifically assessed before starting treatment
• Acute critical illness following complications of open-heart or abdominal surgery, multiple accidental trauma, or acute respiratory failure
• Children with closed epiphyses (growth plates) for growth-promotion purposes
• Proliferative or severe non-proliferative diabetic retinopathy

• Oral corticosteroids (e.g. prednisolone) may reduce the growth-promoting effect of somatropin and require dose adjustment
• Insulin or oral diabetes medicines may need dose adjustment, as somatropin can raise blood sugar levels
• Oestrogen-containing oral contraceptives or hormone therapy may reduce somatropin’s effectiveness in adults
• Thyroid hormone levels should be monitored, as somatropin treatment can unmask or worsen underlying hypothyroidism

• Never adjust your dose without your specialist endocrinologist’s specific guidance
• Attend all scheduled monitoring appointments (growth measurements, IGF-1 levels, blood glucose, and thyroid function tests)
• Follow the specific storage instructions provided with your pen or cartridge, both before and after reconstitution
• Rotate injection sites each time to reduce local skin reactions
• Report any severe headache, vision changes, or persistent vomiting to your doctor promptly
• Do not share your injection device or needles with anyone else, even family members