Glyxambi 25/5mg Tablet
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Prescription Required
Overview
Glyxambi 25/5mg Tablet contains empagliflozin and linagliptin 25/5mg, a combination of an SGLT2 (sodium-glucose co-transporter 2) inhibitor and a DPP-4 (dipeptidyl peptidase-4) inhibitor used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes.
Empagliflozin lowers blood sugar by causing the kidneys to remove excess glucose through the urine, while linagliptin works by increasing levels of incretin hormones that help the pancreas release more insulin and reduce excess glucose production by the liver, particularly after meals.
How it Works
Empagliflozin inhibits SGLT2 transporters in the kidney, reducing glucose reabsorption so that excess sugar is excreted in the urine rather than returned to the bloodstream. Linagliptin blocks the DPP-4 enzyme, which normally breaks down incretin hormones (such as GLP-1); by prolonging their activity, linagliptin increases insulin release and decreases glucagon secretion in a glucose-dependent manner.
Directions for Use
Take Glyxambi 25/5mg Tablet once daily in the morning, with or without food, swallowing the tablet whole with a glass of water. Take it at the same time each day to help maintain steady blood sugar control, and continue your prescribed diet and exercise plan alongside this medicine.
Dosage
The usual dose of Glyxambi 25/5mg Tablet is one tablet (25/5mg) once daily, taken in the morning, with or without food. Your doctor will determine whether this strength and combination is appropriate for you based on your kidney function, current diabetes treatment, and blood sugar control, and may adjust your regimen over time.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Increased urination
- Thirst or dehydration
- Urinary tract infections
- Genital yeast infections
- Low blood sugar (especially when combined with other diabetes medicines)
- Dizziness or light-headedness
Contraindications
- Known hypersensitivity to empagliflozin, linagliptin, or any ingredient in this product
- Type 1 diabetes mellitus or diabetic ketoacidosis
- Severe kidney impairment or end-stage kidney disease/dialysis
- History of serious hypersensitivity reactions to other DPP-4 inhibitors
Drug / Food Interactions
- Insulin or sulfonylureas (e.g. glimepiride) combined with this medicine increase the risk of hypoglycaemia and may require dose adjustment
- Diuretics may add to the fluid-loss and blood-pressure-lowering effects of empagliflozin
- Rifampicin and other strong enzyme inducers may reduce linagliptin’s effectiveness
- Alcohol intake, especially in excess, can increase the risk of low blood sugar and dehydration
Quick Tips
- Drink adequate water to help reduce the risk of dehydration and urinary tract infections
- Practise good genital hygiene to lower the risk of yeast infections associated with SGLT2 inhibitors
- Monitor your blood sugar as advised by your doctor, especially if you are also taking insulin or a sulfonylurea
- Seek prompt medical advice if you feel unusually unwell, even if a routine blood sugar test looks normal, as this could indicate ketoacidosis
- Tell your doctor before any surgery or major illness, as this medicine may need to be temporarily stopped
- Continue following your prescribed diet and exercise programme alongside this medicine
Frequently Asked Questions
What is Glyxambi 25/5mg Tablet used for?
Glyxambi 25/5mg Tablet is used together with diet and exercise to help control blood sugar levels in adults with type 2 diabetes.
Why might I get more urinary tract or yeast infections on this medicine?
Empagliflozin works by increasing glucose excretion through the urine, which can create an environment more prone to urinary tract and genital yeast infections. Good hygiene and adequate hydration can help reduce this risk.
Can this medicine cause low blood sugar (hypoglycaemia)?
On its own, this combination carries a low risk of hypoglycaemia, but the risk increases if combined with insulin or a sulfonylurea. Discuss your specific regimen and warning signs with your doctor.
What is diabetic ketoacidosis and why is it mentioned for this medicine?
SGLT2 inhibitors like empagliflozin have rarely been associated with diabetic ketoacidosis even when blood sugar is not very high. Seek urgent medical attention if you experience nausea, vomiting, abdominal pain, or unusual tiredness.
What should I do if I miss a dose of Glyxambi 25/5mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy Glyxambi 25/5mg Tablet from DoctorOnCall?
Yes, Glyxambi 25/5mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Glyxambi 25/5mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Glyxambi 25/5mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Glyxambi 25/5mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Glyxambi 25/5mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Glyxambi 25/5mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Empagliflozin 25mg
- Linagliptin 5mg
Safety Advice
Pregnancy
This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.
Breastfeeding
Use with caution. Monitor infant for potential adverse reactions.
Kidney
This medicine is not safe for patients with kidney problems.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
Caution is advised when consuming alcohol with this medicine.
Driving
No data is available regarding the effect of this medicine on driving ability.
Medical Review
