HOE Ezerra Plus Cream

HOE Ezerra Plus Cream is a topical cream manufactured by Hoe Pharmaceuticals under the Ezerra brand, formulated with Stimu-tex® AS, Saccharide Isomerate (Pentavitin®), ceramide, and a peptide complex in a cream base. It is categorised as a cosmetic skin cream for dry and sensitive skin types rather than as a registered drug, and is sold as an OTC personal care product through DoctorOnCall.

The product is positioned within the wider Ezerra product range, which also includes a cream, a lotion, and a cleanser, each with a slightly different formulation and texture. Ezerra Plus Cream in particular is formulated as a richer cream suited to skin that requires more intensive care, distinguishing it from the standard Ezerra Cream in the same range.

As an OTC cosmetic cream, Ezerra Plus Cream can be purchased through DoctorOnCall without a prescription. It is sold in tube or jar packaging, with pack sizes as listed on the current DoctorOnCall product page for Malaysia.

• Clean and dry the area of skin to be treated before application.
• Apply a thin, even layer of the cream to the affected area.
• Gently massage the cream into the skin until it is absorbed.
• Apply as needed, or as directed by your pharmacist or doctor, typically up to twice daily.
• Avoid contact with the eyes, mouth, and other mucous membranes.
• Wash your hands after application unless the hands are the area being treated.

HOE Ezerra Plus Cream is a topical cream rather than an oral or injectable medicine, so it does not have a systemic dose in the way a tablet or syrup would. Instead, use is guided by applying a sufficient layer to cover the area of skin being cared for, as described in the Directions for Use.

There is no fixed maximum number of daily applications established for this cosmetic product; follow the frequency on the product packaging or any specific guidance given by your pharmacist or doctor, particularly for long-term or whole-body use.

Use HOE Ezerra Plus Cream before the expiry date printed on the tube, jar, or outer carton. Once opened, use within the period indicated by the PAO (period-after-opening) symbol on the packaging, if present; otherwise, as a general cosmetic cream, it is best used within the timeframe recommended by the manufacturer on the pack.

Store HOE Ezerra Plus Cream at room temperature, below 30°C, away from direct sunlight and excessive heat or humidity. Keep the container tightly closed after each use, and keep the product out of reach of young children.

• Common: mild, temporary stinging or tingling sensation on application, particularly on broken or very dry skin.
• Uncommon: localised redness or itching at the site of application.
• Uncommon: contact dermatitis or a rash in individuals sensitive to one of the cream’s ingredients.
• Rare: more widespread allergic skin reaction, which would need prompt medical attention if it occurs.

• Known hypersensitivity or allergy to Stimu-tex AS, Saccharide Isomerate, ceramide, peptides, or any other ingredient in the cream.
• Broken, infected, or actively weeping skin, unless a doctor or pharmacist has specifically advised use on such areas.
• Avoid applying near or into the eyes or other mucous membranes.

• No clinically significant drug or food interactions are established for this topical cosmetic cream, as it is not absorbed into the bloodstream in a way that is expected to affect oral medicines.
• Avoid applying other topical products with strong active ingredients (such as retinoids, acids, or medicated creams) to the same area at the same time without checking with a pharmacist, to reduce the risk of combined skin irritation.

• Apply to clean, dry skin for the cream to spread and absorb evenly.
• Carry out a small patch test before first use if you have very sensitive or reactive skin.
• Store the cream with the cap or lid tightly closed to keep the formulation stable.
• Keep a consistent daily routine for best results in your overall skin care regimen.
• Avoid sharing your tube or jar with others to maintain hygiene.
• Check the ingredient list on the pack if you are trying a new skincare product alongside this cream.

Precautions: Pregnant or breastfeeding individuals, infants, and people with chronic skin conditions should check with a pharmacist or doctor before starting regular use of HOE Ezerra Plus Cream. Discontinue use and wash off the cream if you notice unexpected redness, swelling, or discomfort after application.

When to See a Doctor or Pharmacist: Speak with a doctor or pharmacist if skin irritation does not settle within a few days of stopping use, if a rash spreads beyond the area of application, or if you are unsure whether this product is appropriate for a specific skin concern, such as a diagnosed skin condition that is not improving.