Jakavi 20mg Tablet

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Manufacturer Novartis
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last reviewed on

Overview

Jakavi 20mg Tablet is a prescription-only medicine (POM) that contains Ruxolitinib 20mg (as ruxolitinib phosphate). It is supplied as a tablet and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, Jakavi 20mg Tablet is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Take Jakavi 20mg Tablet twice daily at approximately 12-hour intervals, with or without food, swallowing the tablet whole. If you cannot swallow tablets, ask your doctor or pharmacist about alternative administration methods rather than crushing the tablet yourself. Do not skip doses or stop this medicine on your own, even temporarily, without your doctor’s explicit instruction.

Dosage

The starting dose of Jakavi 20mg Tablet depends on your specific diagnosis, baseline platelet count, and blood counts, and is individualised and adjusted by your haematologist/oncologist based on your response and regular blood test monitoring. This medicine must only be started, dosed, and adjusted by a specialist experienced in its use – never adjust your own dose.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Headache
  • Dizziness
  • Fatigue
  • Nausea
  • Low blood cell counts (anemia, thrombocytopenia)
  • Increased risk of infections
  • Weight gain

Contraindications

  • Known hypersensitivity to ruxolitinib or any ingredient in this product
  • Pregnancy and breastfeeding
  • Active, serious, or uncontrolled infection (use requires careful specialist assessment)

Drug / Food Interactions

  • Strong CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, certain HIV protease inhibitors) can significantly raise ruxolitinib blood levels, requiring dose adjustment
  • Strong CYP3A4 inducers (e.g. rifampicin, carbamazepine, phenytoin) can reduce ruxolitinib’s effectiveness
  • Fluconazole at commonly used doses requires ruxolitinib dose reduction
  • Other medicines that suppress bone marrow function or increase infection/bleeding risk should be used with caution and discussed with your specialist

Quick Tips

  • This medicine must only be prescribed, dosed, and monitored by a haematologist/oncologist experienced in myeloproliferative disorders or GVHD
  • Attend every scheduled full blood count and other monitoring blood test – regular monitoring for anaemia, low platelets, and low white cell counts is essential
  • Never stop this medicine abruptly on your own; doing so can cause a rapid, sometimes severe, return or worsening of your underlying condition (myelofibrosis symptoms can rebound sharply within days) – any change must be directed by your doctor
  • Report any signs of infection promptly, including fever, as this medicine increases susceptibility to infections including tuberculosis and shingles reactivation
  • Avoid grapefruit and grapefruit juice, as this can raise ruxolitinib blood levels

Ingredients / Active Ingredients

  • Ruxolitinib 20mg (as ruxolitinib phosphate)

Safety Advice

Pregnancy

Not Advisable

Use during pregnancy is generally not recommended unless absolutely necessary.

Breastfeeding

Not Advisable

Generally not recommended while breastfeeding.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Generally Safe

This medicine is generally safe and should not impair your driving ability.

Frequently Asked Questions

Product Specifications

BrandNovartis
ManufacturerNovartis
ClassificationPrescription medicine
Ingredients / Active IngredientsRuxolitinib
Pack Size56s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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