Letrotas 2.5mg Tablet

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Overview

Letrotas 2.5mg Tablet contains letrozole 2.5mg, a non-steroidal aromatase inhibitor used mainly in the treatment of hormone-receptor-positive breast cancer in postmenopausal women. Letrotas is one of several Malaysian letrozole generic brands sharing the “Letr-” name stem. It is sometimes used off-label at a low dose for ovulation induction in certain fertility settings under specialist gynaecological supervision.

Letrozole works by blocking the aromatase enzyme, which is responsible for converting androgens into oestrogen in body tissues. By lowering circulating oestrogen levels, letrozole slows or stops the growth of breast cancer cells that depend on oestrogen to grow.

How it Works

Letrozole selectively and reversibly inhibits the aromatase enzyme, which normally converts androgens into oestrogen in peripheral tissues. In postmenopausal women, this is the main source of circulating oestrogen, so blocking it substantially lowers oestrogen levels, depriving hormone-sensitive breast cancer cells of the oestrogen signal they need to grow.

Directions for Use

Take Letrotas 2.5mg Tablet once daily, at about the same time each day, with or without food. Swallow the tablet whole with a glass of water. Continue taking this medicine for the full duration prescribed by your specialist, even if you feel well, as breast cancer hormonal therapy requires consistent long-term use.

Dosage

The usual dose of Letrotas 2.5mg Tablet for breast cancer treatment is 2.5mg taken once daily, continued for the duration determined by your oncologist based on your specific cancer stage and treatment plan. Never adjust the dose or stop treatment without consulting your specialist, as this is a long-term hormonal therapy that requires consistent use for full benefit.

Shelf Life

Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Hot flashes
  • Fatigue
  • Joint or muscle pain
  • Nausea
  • Headache
  • Dizziness
  • Increased sweating
  • Bone thinning (osteoporosis) with long-term use

Contraindications

  • Known hypersensitivity to letrozole or any ingredient in this product
  • Premenopausal (pre-menopause) hormonal status, unless specifically directed by a specialist for an approved off-label indication
  • Pregnancy and breastfeeding

Drug / Food Interactions

  • Tamoxifen and other oestrogen-containing medicines may reduce letrozole’s effectiveness and are generally avoided together
  • Hormone replacement therapy should generally be avoided during letrozole treatment, as it can counteract its effect
  • Inform your doctor of all other medicines, as letrozole can interact with drugs metabolised through similar liver pathways
  • Regular alcohol use may add to fatigue and should be discussed with your doctor

Quick Tips

  • Attend scheduled bone density (DEXA) scans, as long-term use can reduce bone density and increase fracture risk
  • Report new or worsening bone or joint pain to your doctor
  • Do not take hormone replacement therapy or oestrogen-containing products without checking with your specialist first
  • Keep all follow-up oncology appointments to monitor treatment response
  • Maintain adequate calcium and vitamin D intake, and weight-bearing exercise, as advised by your doctor for bone health

Frequently Asked Questions

What is Letrotas 2.5mg Tablet used for?

Letrotas 2.5mg Tablet contains letrozole and is used mainly to treat hormone-receptor-positive breast cancer in postmenopausal women, by lowering oestrogen levels that can drive cancer cell growth.

Why does letrozole cause hot flushes and joint pain?

Letrozole works by significantly lowering oestrogen levels in the body, and these lower oestrogen levels commonly cause menopause-like symptoms such as hot flushes and joint aches or stiffness.

Does letrozole affect bone health?

Yes, because oestrogen helps protect bone density, long-term letrozole use can reduce bone density and increase fracture risk. Your doctor will typically monitor your bone health with periodic scans and may recommend calcium, vitamin D, or other bone-protective measures.

How long will I need to take this medicine?

Treatment duration for breast cancer is individualised by your oncologist, often continuing for several years as part of extended adjuvant therapy – always follow your specialist’s specific recommendation.

What should I do if I miss a dose of Letrotas 2.5mg Tablet?

Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.

Can I buy Letrotas 2.5mg Tablet from DoctorOnCall?

Yes, Letrotas 2.5mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.

Is the medication provided by DoctorOnCall genuine and safe to use?

DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Letrotas 2.5mg Tablet according to your doctor’s instructions and the information provided with the product.

What payment methods does DoctorOnCall accept?

We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.

Does DoctorOnCall provide an installment payment plan for Letrotas 2.5mg Tablet?

DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.

Is delivery free, and how much does shipping for Letrotas 2.5mg Tablet cost?

Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.

How long does delivery take for Letrotas 2.5mg Tablet?

Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.

What is DoctorOnCall’s shipping, return, or cancellation policy for Letrotas 2.5mg Tablet?

Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.

Ingredients / Active Ingredients

  • Letrozole 2.5mg

Safety Advice

Pregnancy

Not Safe

This medicine is not considered safe during pregnancy and should be avoided.

Breastfeeding

Not Advisable

Generally not recommended while breastfeeding.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Medical Review

Written by:

Dr. Chong Zhan Pong

Doctor of Medicine (MD), International Medical University (IMU)

Reviewed by:

Dr. Mohd Izzat Amir Bin Awang

Doctor of Medicine (MD), University of Mansoura - Manchester

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