Lokelma Powder for Oral Suspension 5g

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Manufacturer AstraZeneca
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Lokelma Powder for Oral Suspension 5g is a prescription-only medicine (POM) presented as an oral suspension, with Sodium zirconium cyclosilicate 5g per sachet as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Empty the entire contents of one sachet into a glass containing approximately 45mL of water, stir well, and drink immediately; if any powder remains, add a small amount of water to the glass, stir, and drink again. Do not use hot water, and do not mix with other liquids or foods unless advised by your doctor. Lokelma may be taken with or without food, based on your doctor’s instructions. Because other oral medicines can bind to Lokelma in the gut and reduce their own absorption, medicines with a narrow therapeutic index should generally be taken at least 2 hours before or 2 hours after Lokelma, or as otherwise directed by your doctor or pharmacist.

Dosage

Treatment usually starts with a correction-phase dose (commonly 10g three times daily for up to 48 hours) to lower blood potassium to the target range, followed by a maintenance dose (commonly starting at 5g once daily) that is adjusted by the doctor based on regular blood potassium monitoring, up to a maximum maintenance dose as advised. The exact dose, duration of the correction phase, and maintenance schedule must be individualised by the treating doctor – do not adjust your dose without medical advice.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children. Use the mixed suspension immediately after preparation.

Side Effects

  • Swelling (oedema), particularly of the legs or ankles
  • Constipation
  • Diarrhoea
  • Low blood potassium (hypokalaemia) if potassium levels fall too far during treatment
  • Urinary tract infection symptoms

Contraindications

  • Known hypersensitivity to sodium zirconium cyclosilicate or any component of the formulation
  • Severe constipation, bowel obstruction, or a history of major gastrointestinal surgery, unless specifically assessed as suitable by a doctor

Drug / Food Interactions

  • May reduce the absorption of other oral medicines if taken at the same time – many medicines should be spaced at least 2 hours apart from Lokelma dosing
  • Increases sodium intake, which may need to be considered in patients on a sodium-restricted diet, such as those with heart failure or hypertension
  • May be used alongside medicines known to raise blood potassium (such as certain ACE inhibitors, ARBs, or potassium-sparing diuretics), but potassium levels should be monitored closely if these are continued together

Quick Tips

  • Always dissolve the full sachet in water and drink immediately, rather than storing the mixed suspension for later
  • Take other oral medicines at least 2 hours before or after Lokelma, unless your doctor advises otherwise
  • Attend all scheduled blood tests, as your doctor will monitor your potassium levels closely during and after treatment
  • Report new or worsening swelling of the legs or ankles to your doctor, as this can be a side effect requiring review

Ingredients / Active Ingredients

  • Sodium zirconium cyclosilicate 5g per sachet

Frequently Asked Questions

Product Specifications

BrandAstraZeneca
ManufacturerAstraZeneca
ClassificationPrescription medicine
Pack Size30s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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