Myleran 2mg Tablet

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Manufacturer AstraZeneca
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last reviewed on

Overview

Myleran 2mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Busulfan 2mg as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Take the tablet exactly as directed by your specialist, at consistent times; do not adjust the dose yourself, as both underdosing and overdosing carry serious risks with this medicine.

Dosage

The dose depends heavily on the indication – lower daily doses are used to control CML blood counts, while much higher doses are used short-term for transplant conditioning – and is individualised and closely monitored by the treating specialist based on blood counts.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children; handle only as directed by your pharmacist, as this is a cytotoxic medicine.

Side Effects

  • Severe suppression of bone marrow function (low white cells, red cells, and platelets)
  • Pulmonary fibrosis (“busulfan lung”) with long-term use – report persistent cough or breathlessness
  • Skin darkening (hyperpigmentation)
  • Nausea and vomiting
  • Reduced fertility and, in women, amenorrhoea (absent periods)

Contraindications

  • Known hypersensitivity to busulfan
  • Pregnancy, due to the risk of serious harm to the developing baby
  • Pre-existing severe bone marrow failure not related to the condition being treated

Drug / Food Interactions

  • Other bone-marrow-suppressing medicines increase the risk of severe low blood counts when combined with busulfan.
  • Paracetamol taken close to high-dose busulfan (in transplant conditioning) can alter its clearance and is managed carefully by the specialist team.
  • Inform your treating specialist of all medicines and supplements you are taking.

Quick Tips

  • Attend every scheduled blood count check, as this medicine requires close monitoring, especially at the start of treatment.
  • Report any new persistent cough, breathlessness, fever, or unusual bruising to your specialist promptly.
  • Discuss fertility concerns with your specialist before starting treatment, as busulfan can affect fertility.
  • Never adjust your dose on your own; contact your specialist team with any concerns first.

Ingredients / Active Ingredients

  • Busulfan 2mg

Frequently Asked Questions

Product Specifications

BrandAstraZeneca
ManufacturerAstraZeneca
ClassificationPrescription medicine
Pack Size25s
Shelf LifeRefer to the expiry date printed on the packaging.

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