Neo-Penotran Pessary

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Neo-Penotran Pessary is a prescription-only medicine (POM) presented as a pessary, with Metronidazole 500mg and Miconazole nitrate 100mg as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Neo-Penotran Pessary is for vaginal use only – it must never be taken by mouth or used in the eyes. Wash your hands before and after insertion, and insert the pessary as high into the vagina as comfortable, preferably at bedtime while lying down, so it is not expelled before it dissolves. You may continue treatment during menstruation; use a sanitary pad rather than a tampon while using this product.

Dosage

The usual regimen is one Neo-Penotran Pessary inserted into the vagina once daily at bedtime, typically for 7 consecutive nights, or as otherwise directed by your doctor based on the severity of your infection. Complete the full course even if your symptoms improve sooner, to reduce the risk of the infection returning.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Nausea or vomiting
  • Metallic taste in the mouth
  • Headache
  • Diarrhea or stomach upset
  • Dizziness
  • Dark-colored urine
  • Mild skin rash

Contraindications

  • Known hypersensitivity to metronidazole, miconazole, or any ingredient in this product
  • First trimester of pregnancy, unless specifically advised by your doctor
  • Not for oral use under any circumstances
  • Avoid alcohol during treatment and for at least 24-48 hours after finishing the course, as metronidazole can cause a disulfiram-like reaction (flushing, nausea, palpitations)

Drug / Food Interactions

  • Alcohol can trigger a disulfiram-like reaction (flushing, nausea, rapid heartbeat) when combined with metronidazole, even with vaginal use
  • Warfarin and other blood-thinning medicines may have an enhanced effect, requiring closer monitoring
  • This product may weaken latex condoms and diaphragms – use an alternative or additional method of contraception during treatment
  • Inform your doctor of all other medicines you are using, including other vaginal products

Quick Tips

  • Insert the pessary at bedtime so you can lie down afterwards and reduce leakage
  • Complete the full course even if symptoms improve after a few days
  • Avoid alcohol during treatment and for 1-2 days after finishing
  • Use a sanitary pad rather than a tampon while using this product
  • Avoid sexual intercourse or use a non-latex barrier method until treatment is finished
  • See your doctor if symptoms do not improve or if irritation worsens

Ingredients / Active Ingredients

  • Metronidazole 500mg
  • Miconazole nitrate 100mg

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Generally Safe

Generally safe, but caution may be required in some patients.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Not Safe

It is not safe to consume alcohol with this medicine as it may cause adverse effects.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandLeon Farma
ClassificationPrescription medicine
Ingredients / Active IngredientsMetronidazole
Pack Size14s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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