Nolvadex-D 20mg Tablet

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Manufacturer AstraZeneca
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Nolvadex-D 20mg Tablet is a prescription-only medicine (POM) that contains Tamoxifen 20mg (as tamoxifen citrate). It is supplied as a tablet and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, Nolvadex-D 20mg Tablet is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Take Nolvadex-D 20mg Tablet at about the same time each day, with or without food, swallowing the tablet whole with a glass of water. Take it regularly as part of your ongoing cancer treatment plan, and keep all scheduled oncology follow-up appointments so your specialist can monitor your response and any side effects.

Dosage

The usual dose of Nolvadex-D 20mg Tablet is 20mg once daily, though your oncologist will confirm the exact dose and duration of treatment (often several years) based on your specific cancer type, stage, and treatment plan. Never change your dose or stop treatment without your specialist’s explicit instruction, as tamoxifen is typically part of a long-term cancer treatment or prevention strategy.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Hot flashes
  • Nausea or upset stomach
  • Fatigue or tiredness
  • Menstrual irregularities
  • Headache
  • Vaginal dryness or discharge
  • Mood changes
  • Leg cramps

Contraindications

  • Known hypersensitivity to tamoxifen or any ingredient in this product
  • Pregnancy (tamoxifen can harm the developing baby)
  • Concurrent use with warfarin without close specialist monitoring (increased bleeding risk)
  • History of venous thromboembolism (blood clots) except where the benefits of treatment are judged by your oncologist to outweigh this risk

Drug / Food Interactions

  • Warfarin’s blood-thinning effect can be significantly increased by tamoxifen, requiring closer INR monitoring
  • Certain antidepressants that strongly inhibit CYP2D6 (e.g. paroxetine, fluoxetine) may reduce the conversion of tamoxifen to its active form and potentially reduce its effectiveness – discuss any antidepressant use with your oncologist
  • Rifampicin and phenytoin may reduce tamoxifen blood levels
  • Inform your oncologist of all medicines and supplements you are taking, as several drugs can affect tamoxifen’s metabolism

Quick Tips

  • Attend all scheduled oncology follow-up visits, including gynaecological and bone health monitoring as advised
  • Report any abnormal vaginal bleeding, leg swelling, or breathlessness to your doctor promptly
  • Never stop or change your dose without your oncologist’s explicit instruction
  • Discuss any new medicine, including antidepressants and over-the-counter products, with your oncologist before starting it
  • Keep a record of your treatment duration, as tamoxifen is often prescribed for several years as part of a long-term plan

Ingredients / Active Ingredients

  • Tamoxifen 20mg (as tamoxifen citrate)

Safety Advice

Pregnancy

Not Advisable

Use during pregnancy is generally not recommended unless absolutely necessary.

Breastfeeding

Not Advisable

Generally not recommended while breastfeeding.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Frequently Asked Questions

Product Specifications

BrandAstraZeneca
ManufacturerAstraZeneca
ClassificationPrescription medicine
Ingredients / Active IngredientsTamoxifen
Pack Size30s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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