Panadeine 500/8mg Tablet
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- Muslim-Friendly
- FDA Approved
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Prescription Required
Overview
Panadeine 500/8mg Tablet combines paracetamol 500mgmg with codeine 8mg (an opioid painkiller) to relieve moderate pain that is not controlled by paracetamol alone, such as headache, dental pain, or musculoskeletal pain.
Paracetamol reduces pain and fever through central mechanisms in the brain and spinal cord, while codeine is converted by the liver to morphine, which binds to opioid receptors to reduce the perception of pain. Combining the two gives stronger pain relief than either ingredient alone.
How it Works
Codeine is metabolised in the liver (via the CYP2D6 enzyme) into morphine, which activates mu-opioid receptors in the brain and spinal cord to blunt pain signalling, while paracetamol acts on separate central pain and temperature-regulating pathways – the combination targets pain through two different mechanisms.
Directions for Use
Take Panadeine 500/8mg Tablet with a full glass of water, with or after food if it upsets your stomach. Do not take more than the labelled maximum dose in 24 hours, and do not take other paracetamol-containing products at the same time, as this risks serious liver damage from paracetamol overdose.
Dosage
Panadeine 500/8mg Tablet is usually taken as 1-2 tablets every 4-6 hours as needed for pain, up to the maximum daily dose stated on the label or advised by your doctor. Because it contains an opioid, it should be used at the lowest effective dose for the shortest time needed, and not used for long-term or chronic pain without medical review.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Drowsiness or dizziness
- Constipation
- Nausea or vomiting
- Dry mouth
- Serious: slow or shallow breathing, extreme drowsiness/difficulty waking, or signs of liver damage (yellowing of the skin/eyes, dark urine, severe abdominal pain) require emergency medical attention
Contraindications
- Known hypersensitivity to paracetamol, codeine, or any ingredient in this product
- Severe respiratory depression or acute severe asthma
- Children below 12 years old, and adolescents 12-18 years with breathing problems
- Known ultra-rapid CYP2D6 metabolisers (a genetic trait that converts codeine to morphine unusually fast)
- Severe liver impairment
Drug / Food Interactions
- Alcohol significantly increases drowsiness and the risk of dangerously slowed breathing when combined with codeine
- Other sedating medicines (sleeping tablets, some antihistamines, other opioids) increase the risk of excessive sedation and breathing difficulty
- Other paracetamol-containing products (including many cold/flu remedies) increase the risk of paracetamol overdose and liver damage
- MAOIs can cause a serious interaction with codeine and should not be combined
Quick Tips
- Never exceed the maximum daily dose, and check other medicines you take for hidden paracetamol content
- Avoid alcohol while taking this medicine
- This medicine can cause drowsiness – avoid driving or operating machinery until you know how it affects you
- Use for the shortest time needed for acute pain; see your doctor if pain persists beyond a few days
Frequently Asked Questions
What is Panadeine 500/8mg Tablet used for?
Panadeine 500/8mg Tablet is used to relieve moderate pain, such as headache, dental pain, or musculoskeletal pain, that is not adequately controlled by paracetamol alone.
Can I become dependent on this medicine?
Because it contains codeine, an opioid, prolonged or frequent use can lead to tolerance and dependence. It should be used at the lowest effective dose for the shortest time necessary, and your doctor should review ongoing use.
Can I drive after taking this medicine?
Codeine can cause drowsiness and slowed reaction times. Avoid driving or operating machinery until you know how this medicine affects you.
Why should I check other medicines for paracetamol before taking this?
Taking more than one paracetamol-containing product at a time can lead to accidental paracetamol overdose, which can cause serious, potentially fatal liver damage. Always check labels of other pain, cold, or flu medicines.
Can I take this medicine for a long time for chronic pain?
This combination is intended for short-term relief of moderate pain. Long-term or chronic pain should be reviewed by your doctor, as prolonged codeine use carries risks of dependence, constipation, and reduced effectiveness.
Can I buy Panadeine 500/8mg Tablet from DoctorOnCall?
Yes, Panadeine 500/8mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Panadeine 500/8mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Panadeine 500/8mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Panadeine 500/8mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Panadeine 500/8mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Panadeine 500/8mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Paracetamol 500mgmg
- Codeine Phosphate 8mg
Safety Advice
Pregnancy
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
Use with caution. Monitor infant for potential adverse reactions.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
No adequate data available. Consult a doctor before use.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
