Primes Cimetidine 400mg Tablet

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

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Overview

Primes Cimetidine 400mg Tablet is supplied as a tablet, with Cimetidine 400mg. It is supplied in a pack size of 10s.

No prescription is required for this product, as it is a non-prescription medicine. This page is limited to product, safety and handling information.

If you would like guidance before buying, you can speak to a doctor or pharmacist through an online consultation on DoctorOnCall. Orders are dispensed by a registered pharmacist and delivered to your address.

Directions for Use

Swallow the tablet whole with a glass of water. Cimetidine 400mg can be taken with or shortly before meals, or as a single dose at bedtime, depending on the pattern of your symptoms. Follow the dosing instructions on the product label or as advised by your pharmacist, and do not exceed the recommended daily amount.

Dosage

The typical adult dose for symptom relief is one 400mg tablet twice daily, or a single 400mg tablet at bedtime for milder, occasional symptoms, for a period of up to two weeks unless a doctor advises otherwise. If heartburn or indigestion symptoms have not improved within two weeks of regular use, stop and see a doctor. This product is not recommended for children without medical advice.

Shelf Life

Primes Cimetidine 400mg Tablet is typically stable for up to 36 months from the date of manufacture when stored correctly and unopened. Always check the expiry date printed on the blister strip or carton before use, and do not use the tablets beyond this date.

Storage Instructions

Store below 30°C in a cool, dry place away from direct sunlight and moisture. Keep the tablets in their original packaging until ready to use, and keep out of the reach and sight of children.

Side Effects

  • Headache
  • Dizziness
  • Diarrhea or constipation
  • Fatigue
  • Muscle or joint pain
  • Skin rash or itching
  • Breast tenderness or enlargement (rare)
  • Confusion, especially in older adults

Contraindications

  • Known hypersensitivity or allergy to cimetidine or any other ingredient in the tablet
  • Use with caution in patients with significant kidney impairment, as dose adjustment may be needed
  • Not recommended for children under 12 years without medical advice
  • Pregnant or breastfeeding women should consult a doctor or pharmacist before use
  • Not intended for long-term or continuous use without medical supervision

Drug / Food Interactions

  • Cimetidine can increase blood levels of warfarin, raising the risk of bleeding — patients on warfarin should seek medical advice before use
  • May increase blood levels of phenytoin and other anti-epileptic medicines
  • Can affect the clearance of theophylline, benzodiazepines (e.g. diazepam), beta-blockers, and some calcium channel blockers, increasing their effects
  • Antacids may reduce cimetidine absorption if taken at the same time — space doses apart where possible
  • Smoking may reduce the effectiveness of cimetidine in healing stomach irritation
  • Always inform your pharmacist of all other medicines you are taking, as cimetidine has a higher interaction potential than newer H2 blockers

Quick Tips

  • Take at the first sign of heartburn or indigestion for best relief
  • Avoid trigger foods such as spicy, fatty, or acidic foods, caffeine, and carbonated drinks while symptomatic
  • Avoid or limit alcohol, which can worsen acid reflux
  • Do not use continuously for more than 2 weeks without consulting a doctor
  • Tell your pharmacist about all other medicines you take before starting this product
  • Eating smaller, more frequent meals and avoiding lying down soon after eating can help reduce symptoms

Ingredients / Active Ingredients

  • Active ingredient: Cimetidine 400mg
  • Other ingredients (excipients) as listed on the product packaging

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Relevant Information

Cimetidine is one of the older H2-receptor antagonists and, while effective, has a greater tendency to interact with other medicines compared with newer options such as famotidine. Seek prompt medical attention if you experience difficulty swallowing, unintentional weight loss, persistent vomiting, vomiting of blood, or black/tarry stools, as these may indicate a more serious underlying condition that needs proper investigation rather than self-treatment.

Frequently Asked Questions

Product Specifications

ClassificationNon-prescription
Ingredients / Active IngredientsCimetidine
Pack Size10s

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Important Medical Information

💊 Recommended Dosage:

The typical adult dose for symptom relief is one 400mg tablet twice daily, or a single 400mg tablet at bedtime for milder, occasional symptoms, for a period of up to two weeks unless a doctor advises otherwise. If heartburn or indigestion symptoms have not improved within two weeks of regular use, stop and see a doctor. This product is not recommended for children without medical advice.

🛑 Contraindications (Do not use if):
  • Known hypersensitivity or allergy to cimetidine or any other ingredient in the tablet
  • Use with caution in patients with significant kidney impairment, as dose adjustment may be needed
  • Not recommended for children under 12 years without medical advice
  • Pregnant or breastfeeding women should consult a doctor or pharmacist before use
  • Not intended for long-term or continuous use without medical supervision
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Headache
  • Dizziness
  • Diarrhea or constipation
  • Fatigue
  • Muscle or joint pain
  • Skin rash or itching
  • Breast tenderness or enlargement (rare)
  • Confusion, especially in older adults
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.