Ranexa 375mg Tablet
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Overview
Ranexa 375mg Tablet contains ranolazine 375mg in an extended-release tablet, an anti-anginal medicine used to treat chronic stable angina (recurring chest pain due to reduced blood flow to the heart), usually as add-on therapy when other angina medicines have not fully controlled symptoms.
Ranolazine works differently from most other angina medicines: it inhibits the late inward sodium current in heart muscle cells, which reduces excess calcium build-up inside the cells. This improves the heart muscle’s ability to relax between beats and reduces the mismatch between oxygen supply and demand that causes angina pain, without significantly changing your heart rate or blood pressure.
How it Works
Ranolazine selectively inhibits the late inward sodium current (late INa) in heart muscle cells. By reducing sodium entry, it lowers the resulting build-up of intracellular calcium, which improves diastolic (relaxation-phase) function of the heart muscle and reduces the oxygen demand that triggers angina, without the heart-rate- or blood-pressure-lowering effects typical of other anti-anginal drug classes.
Directions for Use
Take Ranexa 375mg Tablet with or without food, but be consistent with how you take it each time. Swallow the tablet whole – do not crush, chew, or split it, as this is an extended-release formulation designed to release the medicine slowly over the day. Avoid grapefruit juice while taking this medicine.
Dosage
Ranexa 375mg Tablet is usually taken twice daily, with your doctor typically starting at a lower dose and adjusting the strength over time based on your symptom control and tolerability, up to a maximum recommended dose. This tablet strength reflects one step in that individualised titration.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Dizziness
- Constipation
- Nausea
- Headache
- Fatigue
- Dry mouth
- Palpitations
- Abdominal discomfort
Contraindications
- Known hypersensitivity to ranolazine or any ingredient in this product
- Clinically significant liver impairment
- Concomitant use with strong CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, certain HIV protease inhibitors) or strong CYP3A4 inducers (e.g. rifampicin, phenytoin, carbamazepine, St John’s Wort)
- Pre-existing prolongation of the QT interval on ECG
Drug / Food Interactions
- Strong or moderate CYP3A4 inhibitors significantly raise ranolazine levels and increase the risk of side effects – some combinations are contraindicated
- Ranolazine increases blood levels of digoxin and simvastatin; your doctor may need to limit your simvastatin dose or monitor digoxin levels more closely
- Grapefruit juice inhibits the same enzyme that clears ranolazine and can raise its levels – avoid grapefruit juice and grapefruit products
- Other medicines that prolong the QT interval may add to the risk of heart rhythm disturbances
Quick Tips
- Swallow the tablet whole – never crush, chew, or split it
- Avoid grapefruit juice and grapefruit products throughout treatment
- Report palpitations, a fast or irregular heartbeat, or fainting to your doctor promptly
- Continue taking your other prescribed angina medicines unless your doctor tells you to stop
- Keep to your doctor’s plan for a fast-acting nitrate (if prescribed) for sudden chest pain, as this medicine is not for immediate relief of an angina attack
Frequently Asked Questions
What is Ranexa 375mg Tablet used for?
Ranexa 375mg Tablet is used to treat chronic stable angina, usually as an add-on medicine when angina is not fully controlled by first-line treatments such as beta-blockers or calcium channel blockers.
Can I use this medicine to relieve sudden chest pain?
No. This is a maintenance medicine taken regularly to reduce how often angina occurs – it does not act quickly enough to relieve a sudden attack. Continue using any fast-acting nitrate your doctor has prescribed for sudden chest pain.
Why must I avoid grapefruit juice with this medicine?
Grapefruit juice blocks the same liver enzyme (CYP3A4) that breaks down ranolazine, which can raise ranolazine levels in your blood and increase the risk of side effects, including heart rhythm changes.
Why do the different Ranexa tablet strengths exist?
Ranolazine is usually started at a lower dose and increased gradually based on how well your angina is controlled and how well you tolerate the medicine – the different strengths allow your doctor to titrate your dose safely.
What should I do if I miss a dose of Ranexa 375mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy Ranexa 375mg Tablet from DoctorOnCall?
Yes, Ranexa 375mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Ranexa 375mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Ranexa 375mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Ranexa 375mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Ranexa 375mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Ranexa 375mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Ranolazine 375mg (extended-release)
Safety Advice
Pregnancy
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
Use with caution. Monitor infant for potential adverse reactions.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Not recommended in patients with liver disease.
Alcohol
Caution is advised when consuming alcohol with this medicine.
Driving
It is not advisable to drive if you experience side effects from this medicine.
Medical Review
