Ranexa 375mg Tablet

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Manufacturer A. Menarini
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

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Overview

Ranexa 375mg Tablet contains Ranolazine 375mg (extended-release) and is available as a tablet. It is classified as a prescription medicine and may only be obtained with a valid prescription from a registered medical practitioner.

Only product, safety and handling information is published here. Anything beyond that is explained to you directly by your doctor or pharmacist as part of your consultation.

DoctorOnCall is a licensed online pharmacy. Orders for Ranexa 375mg Tablet are processed only after a doctor has assessed your suitability and issued a prescription, and every order is checked by a registered pharmacist before it is sent out.

Directions for Use

Take Ranexa 375mg Tablet with or without food, but be consistent with how you take it each time. Swallow the tablet whole – do not crush, chew, or split it, as this is an extended-release formulation designed to release the medicine slowly over the day. Avoid grapefruit juice while taking this medicine.

Dosage

Ranexa 375mg Tablet is usually taken twice daily, with your doctor typically starting at a lower dose and adjusting the strength over time based on your symptom control and tolerability, up to a maximum recommended dose. This tablet strength reflects one step in that individualised titration.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Dizziness
  • Constipation
  • Nausea
  • Headache
  • Fatigue
  • Dry mouth
  • Palpitations
  • Abdominal discomfort

Contraindications

  • Known hypersensitivity to ranolazine or any ingredient in this product
  • Clinically significant liver impairment
  • Concomitant use with strong CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, certain HIV protease inhibitors) or strong CYP3A4 inducers (e.g. rifampicin, phenytoin, carbamazepine, St John’s Wort)
  • Pre-existing prolongation of the QT interval on ECG

Drug / Food Interactions

  • Strong or moderate CYP3A4 inhibitors significantly raise ranolazine levels and increase the risk of side effects – some combinations are contraindicated
  • Ranolazine increases blood levels of digoxin and simvastatin; your doctor may need to limit your simvastatin dose or monitor digoxin levels more closely
  • Grapefruit juice inhibits the same enzyme that clears ranolazine and can raise its levels – avoid grapefruit juice and grapefruit products
  • Other medicines that prolong the QT interval may add to the risk of heart rhythm disturbances

Quick Tips

  • Swallow the tablet whole – never crush, chew, or split it
  • Avoid grapefruit juice and grapefruit products throughout treatment
  • Report palpitations, a fast or irregular heartbeat, or fainting to your doctor promptly
  • Continue taking your other prescribed angina medicines unless your doctor tells you to stop
  • Keep to your doctor’s plan for a fast-acting nitrate (if prescribed) for sudden chest pain, as this medicine is not for immediate relief of an angina attack

Ingredients / Active Ingredients

  • Ranolazine 375mg (extended-release)

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Not Advisable

Not recommended in patients with liver disease.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Frequently Asked Questions

Product Specifications

BrandA. Menarini
ManufacturerA. Menarini
ClassificationPrescription medicine
Ingredients / Active IngredientsRanolazine
Pack Size60s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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