Repatha (Evolocumab) 140mg/ml Solution for Injection

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Brand Amgen
Manufacturer Amgen
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

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Overview

Repatha Evolocumab 140mg/ml Solution for Injection is a prescription-only medicine (POM) that contains Evolocumab 140mg/mL solution for injection. It is supplied as an injection and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, Repatha Evolocumab 140mg/ml Solution for Injection is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Repatha Evolocumab 140mg/ml Solution for Injection is injected subcutaneously (under the skin) into the abdomen, thigh, or upper arm; rotate the injection site with each dose and avoid areas that are tender, bruised, red, or hard. Remove the pre-filled pen or syringe from the refrigerator and allow it to reach room temperature for about 30 minutes before injecting – do not warm it artificially (e.g. with hot water or a microwave). A doctor, nurse, or pharmacist will teach you the correct injection technique before you self-administer at home.

Dosage

Repatha Evolocumab 140mg/ml Solution for Injection is typically given as 140mg by subcutaneous injection every 2 weeks, or as 420mg (three consecutive injections) once monthly, depending on your condition and your doctor’s recommendation. This medicine is used together with a statin (and sometimes other lipid-lowering treatment) in most patients, not as a substitute for them, unless your doctor specifically advises otherwise.

Storage Instructions

Store in a refrigerator (2-8°C). Do not freeze. Keep the pre-filled pen or syringe in the original carton to protect it from light. If needed, it may be kept at room temperature (up to 25°C) for a limited period as advised by your pharmacist, but once removed from the refrigerator it should not be returned to it.

Side Effects

  • Injection site reactions (redness, pain, bruising, or swelling)
  • Back pain
  • Symptoms of upper respiratory tract infection
  • Flu-like symptoms
  • Serious: signs of a severe allergic reaction (rash, swelling of the face/lips/throat, difficulty breathing) require immediate medical attention

Contraindications

  • Known hypersensitivity to evolocumab or any ingredient in this product

Drug / Food Interactions

  • As a monoclonal antibody, evolocumab is not metabolised by liver enzymes and has minimal drug-drug interactions
  • It is intended to be used together with a statin (and sometimes ezetimibe) in most patients, not as a replacement – do not stop your statin without your doctor’s advice
  • No specific food interactions are expected, but continue following any dietary advice given by your doctor for cholesterol management

Quick Tips

  • Keep this medicine refrigerated and let it warm to room temperature for about 30 minutes before injecting
  • Rotate injection sites (abdomen, thigh, upper arm) to reduce skin irritation
  • Do not stop your statin or other cholesterol medicines unless your doctor tells you to
  • Attend scheduled cholesterol (lipid panel) checks to monitor your response to treatment
  • Learn the proper injection technique from your healthcare provider and follow the same schedule (every 2 weeks or monthly) consistently

Ingredients / Active Ingredients

  • Evolocumab 140mg/mL solution for injection

Frequently Asked Questions

Product Specifications

BrandAmgen
ManufacturerAmgen
ClassificationPrescription medicine
Pack Contents1ml x1
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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