Revolade 25 mg Tablet
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Prescription Required
Overview
Revolade 25 mg Tablet contains eltrombopag 25mg, an oral thrombopoietin receptor agonist used to raise low platelet counts (thrombocytopenia) in conditions such as chronic immune thrombocytopenia (ITP), thrombocytopenia associated with chronic hepatitis C, and severe aplastic anaemia that has not responded adequately to other treatments.
Eltrombopag works by binding to and activating the thrombopoietin receptor on bone marrow cells, mimicking the action of the body’s natural thrombopoietin hormone. This stimulates the growth and maturation of megakaryocytes, the bone marrow cells that produce platelets, leading to an increase in circulating platelet count.
How it Works
Eltrombopag binds to the transmembrane domain of the thrombopoietin receptor (TPO-R, also called MPL) on megakaryocyte progenitor cells in the bone marrow, activating signalling pathways that stimulate proliferation and differentiation of these cells into mature, platelet-producing megakaryocytes. This increases platelet production without directly affecting platelet aggregation.
Directions for Use
Take Revolade 25 mg Tablet on an empty stomach, at least 2 hours before or 4 hours after any food or supplement containing calcium or other polyvalent cations (see interactions below), as these significantly reduce its absorption. Swallow the tablet whole with a full glass of water, at about the same time each day.
Dosage
The starting dose of Revolade 25 mg Tablet is usually 50mg once daily (or 25mg in some patients, such as those of East Asian ancestry or with liver impairment), and your doctor will adjust it every 2 weeks based on your platelet count response, up to a maximum of 75mg daily. Treatment requires regular blood tests, and your doctor will individualise both the dose and the duration of treatment for your condition.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Nausea
- Headache
- Fatigue
- Diarrhea
- Muscle aches
- Elevated liver enzymes
- Skin rash
- Loss of appetite
Contraindications
- Known hypersensitivity to eltrombopag or any ingredient in this product
- Use with caution in patients with liver impairment, who require closer monitoring and often a lower starting dose
- Not generally recommended in pregnancy unless the potential benefit outweighs the risk, as assessed by your doctor
Drug / Food Interactions
- Antacids, dairy products, calcium-fortified foods, and multivitamins or supplements containing iron, calcium, magnesium, aluminium, selenium, or zinc markedly reduce absorption – take at least 2 hours apart
- Statins (e.g. rosuvastatin) may reach higher blood levels when combined with eltrombopag, so your doctor may adjust the statin dose
- Other medicines that are substrates of certain liver transport proteins (OATP1B1, BCRP) may interact – inform your doctor of all medicines you take
Quick Tips
- Attend all scheduled blood tests to monitor your platelet count and liver function
- Separate this medicine from antacids, calcium, iron, and multivitamins by several hours
- Report unusual bruising, bleeding, or signs of jaundice to your doctor promptly
- Do not stop this medicine abruptly without medical advice, as platelet counts may drop again
- Keep a record of your platelet count results between doctor visits
Frequently Asked Questions
What is Revolade 25 mg Tablet used for?
Revolade 25 mg Tablet is used to raise low platelet counts in conditions such as chronic immune thrombocytopenia (ITP), thrombocytopenia linked to chronic hepatitis C treatment, and severe aplastic anaemia that has not responded well to other treatments.
Why must I take this medicine away from food and supplements?
Eltrombopag binds strongly to calcium and other minerals such as iron, magnesium, aluminium, and zinc, which prevents it from being absorbed properly. Taking it at least 2 hours before or 4 hours after these products ensures you get the full benefit of the medicine.
How will my doctor know if the dose is working?
Your doctor will check your platelet count regularly, usually every 2 weeks initially, and adjust your dose based on the result. Liver function tests are also monitored periodically during treatment.
Can I stop taking this medicine once my platelet count improves?
Do not stop or change your dose without consulting your doctor, as platelet counts often fall again after stopping, and abrupt discontinuation can increase bleeding risk in some conditions.
What should I do if I miss a dose of Revolade 25 mg Tablet?
Skip the missed dose and take your next dose at the usual time the next day. Do not take a double dose to make up for a missed one, and do not take more than one dose in a day.
Can I buy Revolade 25 mg Tablet from DoctorOnCall?
Yes, Revolade 25 mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Revolade 25 mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Revolade 25 mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Revolade 25 mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Revolade 25 mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Revolade 25 mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Eltrombopag 25mg (as eltrombopag olamine)
Safety Advice
Pregnancy
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
Limited data on excretion in breast milk. Consult a doctor before use.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
Caution is advised when consuming alcohol with this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
