Sabril 500mg Tablet
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Overview
Sabril 500mg Tablet contains vigabatrin 500mg, an anticonvulsant (anti-epileptic) medicine used together with other anti-epileptic drugs to treat refractory partial epilepsy that has not responded adequately to other treatments, and as a standalone treatment for infantile spasms (West syndrome).
Vigabatrin works by irreversibly blocking the enzyme that breaks down GABA (gamma-aminobutyric acid), a natural calming neurotransmitter in the brain. This raises brain GABA levels, which reduces the abnormal electrical activity that causes seizures.
How it Works
Vigabatrin selectively and irreversibly inhibits GABA-transaminase, the enzyme responsible for breaking down GABA in the brain. By preventing this breakdown, vigabatrin increases the amount of GABA available to dampen excessive nerve signalling, which helps control seizure activity.
Directions for Use
Take Sabril 500mg Tablet exactly as prescribed, usually in two divided doses per day, with or without food. Do not stop or change the dose without your doctor’s guidance, as abruptly stopping an anti-epileptic medicine can trigger seizures or, in some cases, prolonged seizure activity (status epilepticus).
Dosage
The dose of Sabril 500mg Tablet is individualised by your doctor based on age, body weight, seizure type, and response, and is usually started low and titrated gradually to the effective dose. Your doctor will schedule regular visual field testing and clinical reviews throughout treatment to balance seizure control against the risk of visual side effects.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Drowsiness or dizziness
- Fatigue
- Blurred or double vision
- Weight gain
- Difficulty concentrating
- Peripheral vision loss (rare but serious)
Contraindications
- Known hypersensitivity to vigabatrin or any ingredient in this product
- Pre-existing significant visual field defect (used only if benefits clearly outweigh risks, under close specialist supervision)
- Significant unexplained psychiatric illness, unless under specialist psychiatric review
Drug / Food Interactions
- Phenytoin blood levels may be reduced when combined with vigabatrin
- Other central nervous system depressants (e.g. sedatives, alcohol) may increase drowsiness
- Clonazepam and other anti-epileptic drugs may have an additive sedative effect
Quick Tips
- Attend every scheduled ophthalmological (eye) examination, including baseline and regular follow-up visual field testing, for as long as you take this medicine and for some time after stopping
- Never stop this medicine suddenly without your doctor’s advice
- Tell your doctor immediately if you or your child notices any change in vision, such as bumping into objects or difficulty seeing to the side
- Avoid driving or operating machinery until you know how this medicine affects you, especially your vision and alertness
- Keep a seizure diary to help your specialist assess how well the medicine is working
Frequently Asked Questions
What is Sabril 500mg Tablet used for?
Sabril 500mg Tablet is used together with other anti-epileptic medicines for epilepsy that has not responded to other treatments, and alone for infantile spasms in infants.
Why do I need regular eye examinations while taking this medicine?
Vigabatrin is well known to cause permanent, irreversible narrowing of the visual field in a significant proportion of patients, which can occur without any warning symptoms, so regular ophthalmological visual field testing is essential to detect this early.
Is the visual field damage reversible if I stop the medicine?
No, the visual field constriction associated with vigabatrin is generally considered permanent even after stopping treatment, which is why the decision to start and continue this medicine is always made carefully by a specialist, weighing seizure control against this risk.
Can I stop this medicine suddenly if I feel better?
No, anti-epileptic medicines like vigabatrin must never be stopped abruptly, as this can trigger a return of seizures or, rarely, a dangerous prolonged seizure – any change in treatment must be planned and supervised by your doctor.
What should I do if I miss a dose of Sabril 500mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy Sabril 500mg Tablet from DoctorOnCall?
Yes, Sabril 500mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Sabril 500mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Sabril 500mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Sabril 500mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Sabril 500mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Sabril 500mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Vigabatrin 500mg
Safety Advice
Pregnancy
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
Limited data on excretion in breast milk. Consult a doctor before use.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Generally safe, but caution may be required in some patients.
Alcohol
Limited data is available regarding the effects of alcohol with this medicine.
Driving
This medicine is generally safe and should not impair your driving ability.
Medical Review
