Savagen 24mg/26mg Film Coated Tablets

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Manufacturer Novugen
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Savagen 24mg/26mg Film Coated Tablets contains Sacubitril 24mg and Valsartan 26mg and is available as a tablet. It is classified as a prescription medicine and may only be obtained with a valid prescription from a registered medical practitioner.

Only product, safety and handling information is published here. Anything beyond that is explained to you directly by your doctor or pharmacist as part of your consultation.

DoctorOnCall is a licensed online pharmacy. Orders for Savagen 24mg/26mg Film Coated Tablets are processed only after a doctor has assessed your suitability and issued a prescription, and every order is checked by a registered pharmacist before it is sent out.

Directions for Use

Savagen tablets are taken orally, with or without food, twice daily at evenly spaced times. Swallow the tablet whole with water. If a dose is missed, take it as soon as remembered unless it is almost time for the next dose, in which case the missed dose should be skipped – do not double the next dose.

Dosage

The usual starting dose for patients new to ARNI therapy, or switching from a low dose of an ACE inhibitor or ARB, is Savagen 24mg/26mg twice daily. The doctor will typically double the dose every 2 to 4 weeks as tolerated, up to a target maintenance dose, based on blood pressure, kidney function, and potassium levels. If switching from an ACE inhibitor, a washout period of at least 36 hours is required before starting Savagen. The exact starting dose, titration schedule, and target dose must be determined by the treating doctor – never change your dose or switch medicines without medical advice.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Dizziness or light-headedness
  • Low blood pressure
  • Cough
  • Fatigue
  • Increased potassium levels (hyperkalemia)
  • Kidney function changes

Contraindications

  • Known hypersensitivity to sacubitril, valsartan, or any component of the formulation
  • Concurrent use with an ACE inhibitor, or use within 36 hours of stopping an ACE inhibitor, due to the risk of angioedema
  • History of angioedema related to previous ACE inhibitor or ARB treatment
  • Pregnancy – this medicine can cause harm to the developing baby
  • Severe liver impairment

Drug / Food Interactions

  • Must not be combined with ACE inhibitors due to the increased risk of angioedema – a 36-hour washout period is required between the two
  • Combining with potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium may increase the risk of high blood potassium
  • NSAIDs (such as ibuprofen) may reduce the effectiveness of this medicine and increase the risk of kidney problems, especially in older adults or those who are dehydrated
  • Lithium levels may increase when combined with this medicine – dose adjustment and monitoring may be required

Quick Tips

  • Take your doses at evenly spaced times each day to maintain consistent blood levels
  • Attend all scheduled blood tests to monitor kidney function and potassium levels
  • Tell every doctor or pharmacist you see that you are taking Savagen, especially before starting any new ACE inhibitor
  • Seek urgent medical attention if you notice swelling of the face, lips, tongue, or throat, or difficulty breathing, as this can indicate angioedema

Ingredients / Active Ingredients

  • Sacubitril 24mg
  • Valsartan 26mg

Safety Advice

Pregnancy

Not Advisable

Use during pregnancy is generally not recommended unless absolutely necessary.

Breastfeeding

Not Advisable

Generally not recommended while breastfeeding.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandNovugen Pharma
ManufacturerNovugen
ClassificationPrescription medicine
Ingredients / Active IngredientsSacubitril + Valsartan
Pack Size30s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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