Spizef 250mg Tablet

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Spizef 250mg Tablet is a prescription-only medicine (POM) that contains Cefuroxime Axetil 250mg. It is supplied as a tablet and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, Spizef 250mg Tablet is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Take with food, as this improves absorption of cefuroxime axetil and reduces stomach upset. Swallow the tablet whole; do not crush or chew it, as this can affect how well the medicine is absorbed.

Dosage

The usual adult dose is 250mg to 500mg twice daily, depending on the type and severity of the infection, for a course usually lasting 5 to 10 days as prescribed by your doctor. Complete the full course even if you feel better before it is finished, to help prevent antibiotic resistance and recurrence of infection.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Nausea or vomiting
  • Diarrhoea
  • Headache
  • Abdominal pain
  • Skin rash or itching
  • Dizziness

Contraindications

  • Known hypersensitivity to cefuroxime or other cephalosporin antibiotics
  • Immediate or severe hypersensitivity reaction (such as anaphylaxis) to penicillins
  • Use with caution in patients with significant kidney impairment (dose adjustment may be needed)

Drug / Food Interactions

  • Antacids and acid-reducing medicines (H2 blockers, proton pump inhibitors) – may reduce the absorption of cefuroxime axetil
  • Probenecid – can increase and prolong cefuroxime blood levels
  • Oral contraceptives – antibiotics may occasionally reduce contraceptive effectiveness; consider additional contraceptive precautions
  • Inform your doctor of all other medicines you are taking before starting this antibiotic

Quick Tips

  • Complete the full course of antibiotics even if you start to feel better
  • Take with food to improve absorption and reduce stomach upset
  • Tell your doctor if you have a history of severe allergic reaction to penicillin before starting
  • Seek medical advice if you develop severe or persistent diarrhoea during or after treatment

Ingredients / Active Ingredients

  • Cefuroxime Axetil 250mg

Safety Advice

Pregnancy

Safe If Prescribed

This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

ClassificationPrescription medicine
Ingredients / Active IngredientsCefuroxime
Pack Size10s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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