Tegretol CR 400mg Tablet

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last updated:

Overview

Tegretol CR 400mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Carbamazepine 400mg (controlled-release) as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Swallow Tegretol CR 400mg Tablet tablets whole with a glass of water – do not crush, chew, or break the tablet, as this is a controlled-release formulation designed to release the medicine slowly over time. Take at consistent times each day, with or without food, and never switch to a different brand or generic version of carbamazepine without your doctor’s specific instruction, as differences in formulation can affect seizure control or increase side effects.

Dosage

Tegretol CR 400mg Tablet dosing is individualised and usually started at a low dose, increased gradually by your doctor based on your response and blood levels, since both the seizure-control effect and the risk of side effects depend closely on the exact dose. Regular blood tests to check carbamazepine levels, blood counts, and liver function are typically required.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Dizziness or drowsiness
  • Nausea or vomiting
  • Blurred or double vision
  • Skin rash or allergic reactions
  • Swelling of face or lips (seek medical attention)
  • Low sodium levels (may cause confusion or seizures)
  • Tiredness or weakness
  • Coordination problems

Contraindications

  • Known hypersensitivity to carbamazepine or chemically related medicines (e.g. tricyclic antidepressants)
  • History of bone marrow suppression or blood disorders
  • AV conduction abnormalities (heart block) unless a pacemaker is fitted
  • Concomitant use with monoamine oxidase inhibitors (MAOIs)
  • History of acute intermittent porphyria

Drug / Food Interactions

  • Hormonal contraceptives: carbamazepine is a strong enzyme inducer and can significantly reduce their effectiveness, so alternative or additional contraception should be discussed with your doctor
  • Warfarin and many other medicines metabolised by the liver: carbamazepine can reduce their blood levels and effectiveness
  • Grapefruit juice can increase carbamazepine blood levels and the risk of side effects
  • Other antiepileptic medicines: complex interactions can occur in either direction, so combination therapy requires specialist monitoring

Quick Tips

  • Never switch between different brands or generic versions of carbamazepine without your doctor’s explicit instruction, due to its narrow therapeutic index
  • Attend all scheduled blood tests to monitor carbamazepine levels, blood counts, and liver function
  • Seek immediate medical attention for any new widespread skin rash, especially with fever or mouth sores, as this can be a serious, potentially life-threatening reaction
  • Ask your doctor about genetic testing (HLA-B*1502) if you are of Southeast Asian or Chinese ancestry, as this genetic marker is more common in these populations and is associated with a higher risk of severe skin reactions to carbamazepine

Ingredients / Active Ingredients

  • Carbamazepine 400mg (controlled-release)

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandNovartis
ClassificationPrescription medicine
Ingredients / Active IngredientsCarbamazepine
Pack Size10s, 200s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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