Nexium 20mg Tablet
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Prescription Required
Overview
Nexium 20mg Tablet contains esomeprazole 20mg, a proton pump inhibitor (PPI) and the active S-isomer of omeprazole, used to reduce the amount of acid produced in the stomach. It is used to treat gastro-oesophageal reflux disease (GERD), peptic ulcers, and other acid-related digestive conditions.
Esomeprazole works by irreversibly binding to the hydrogen-potassium ATPase (proton pump) in the acid-producing cells of the stomach lining, blocking the final step of gastric acid secretion. This significantly reduces stomach acidity, relieving reflux symptoms and allowing irritated or damaged tissue in the oesophagus or stomach to heal.
How it Works
Esomeprazole accumulates in the acidic environment of the stomach’s parietal cells, where it irreversibly binds to and inactivates the proton pump responsible for the final step of gastric acid secretion. Because this binding is irreversible, acid suppression continues until the body produces new proton pumps, giving a sustained reduction in stomach acidity.
Directions for Use
Take Nexium 20mg Tablet once daily, at least one hour before a meal, swallowing the tablet whole with a glass of water. Do not crush, chew, or split the tablet, as this would destroy the coating that protects the medicine from stomach acid before it is absorbed.
Dosage
The usual adult dose of Nexium 20mg Tablet is one tablet once daily, though your doctor may adjust the dose and duration depending on the condition being treated – for example, H. pylori eradication regimens are typically shorter courses, while GERD maintenance treatment may continue for longer. Always follow your doctor’s specific instructions.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Headache
- Diarrhoea or constipation
- Abdominal pain
- Nausea or vomiting
- Bloating or gas
- Dizziness
- Dry mouth
Contraindications
- Known hypersensitivity to esomeprazole or other proton pump inhibitors (including substituted benzimidazoles)
- Concurrent use with nelfinavir, an HIV medicine that requires stomach acid for absorption
Drug / Food Interactions
- Clopidogrel’s antiplatelet effect may be reduced when combined with esomeprazole, as both are metabolised via the CYP2C19 enzyme – discuss with your doctor if you take clopidogrel
- Reduces absorption of medicines that require an acidic stomach environment, such as ketoconazole and atazanavir
- Methotrexate blood levels may increase when combined with high-dose esomeprazole, particularly with high-dose methotrexate regimens
- Digoxin absorption may be altered, and long-term use may reduce absorption of vitamin B12, calcium, and magnesium
Quick Tips
- Take at least one hour before a meal for the most consistent acid-suppressing effect
- Swallow the tablet whole – do not crush, chew, or split it
- Report severe or persistent diarrhoea to your doctor, especially if it develops during or after treatment
- Discuss any long-term use with your doctor, as prolonged PPI therapy is periodically reviewed
- Inform your doctor if you are taking clopidogrel, methotrexate, or HIV medicines
Frequently Asked Questions
What is Nexium 20mg Tablet used for?
Nexium 20mg Tablet is used to reduce stomach acid production and treat conditions such as gastro-oesophageal reflux disease, peptic ulcers, and, as part of combination therapy, Helicobacter pylori infection.
How long does it take for esomeprazole to relieve symptoms?
Many people notice improvement in reflux symptoms within a few days, though it can take up to 4-8 weeks of regular use for oesophagitis or ulcers to fully heal.
Can I take this medicine together with clopidogrel?
Esomeprazole may reduce the effectiveness of clopidogrel in some patients because both are processed by the same liver enzyme. If you take clopidogrel for a heart condition, discuss this combination with your doctor before starting esomeprazole.
Can I take this medicine long-term?
Esomeprazole can be used long-term for certain conditions under medical supervision, but your doctor will periodically review the ongoing need for treatment, as prolonged acid suppression has been associated with certain risks, including effects on bone health and magnesium levels.
Should I take this medicine before or after food?
Esomeprazole is generally most effective when taken at least one hour before a meal, as this timing allows the medicine to be absorbed and become active before your stomach produces acid in response to food.
What should I do if I miss a dose of Nexium 20mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy Nexium 20mg Tablet from DoctorOnCall?
Yes, Nexium 20mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Nexium 20mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Nexium 20mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Nexium 20mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Nexium 20mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Nexium 20mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Esomeprazole 20mg (as esomeprazole magnesium trihydrate)
Safety Advice
Pregnancy
There is no adequate data on use during pregnancy. Consult a doctor before use.
Breastfeeding
Limited data on excretion in breast milk. Consult a doctor before use.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
No data is available regarding the interaction of alcohol with this medicine.
Driving
This medicine is generally safe and should not impair your driving ability.
Medical Review
