Salazopyrin En 500mg Tablet

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Brand Pfizer
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  • Muslim-Friendly
  • FDA Approved
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Overview

Salazopyrin En 500mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Sulfasalazine 500mg as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Swallow Salazopyrin En 500mg Tablet tablets whole with a full glass of water, preferably after meals to reduce stomach upset; do not crush or chew the tablet, as this may destroy the enteric coating that protects it from stomach acid. Take the doses evenly spaced through the day as directed by your doctor, and drink plenty of fluids while on treatment.

Dosage

The usual dose of Salazopyrin En 500mg Tablet varies by condition: for ulcerative colitis, doses typically range from 2-4g daily in divided doses during a flare, reducing to a lower maintenance dose; for rheumatoid arthritis, treatment is usually started at a low dose and gradually increased. Your doctor will individualise the dose and monitoring schedule for your condition.

Side Effects

  • Headache
  • Nausea or vomiting
  • Loss of appetite
  • Rash or skin sensitivity
  • Dizziness
  • Temporary infertility in men (reversible)
  • Stomach upset
  • Orange-yellow discoloration of urine or skin

Contraindications

  • Known hypersensitivity to sulfasalazine, sulfonamides, or salicylates
  • Porphyria
  • Intestinal or urinary tract obstruction
  • Severe liver or kidney impairment

Drug / Food Interactions

  • Folic acid absorption may be reduced with long-term use, so a folic acid supplement may be recommended
  • Digoxin blood levels may be reduced when taken with sulfasalazine
  • Warfarin’s blood-thinning effect may be enhanced, requiring closer monitoring
  • Azathioprine or mercaptopurine may increase the risk of blood-related side effects when combined

Quick Tips

  • Do not be alarmed if your urine, skin, or contact lenses take on an orange-yellow tinge – this is a harmless, expected effect of the medicine
  • Consider using glasses instead of soft contact lenses while on treatment, as lenses can become permanently stained
  • Drink plenty of water throughout the day while taking this medicine
  • Attend all scheduled blood tests to monitor for blood and liver-related side effects, especially in the first few months
  • Ask your doctor about folic acid supplementation if you are on long-term treatment

Ingredients / Active Ingredients

  • Sulfasalazine 500mg

Safety Advice

Pregnancy

Limited Data

Limited information is available regarding use during pregnancy. Use only if clearly needed.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Limited Data

Limited data available in liver disease patients.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Frequently Asked Questions

Product Specifications

BrandPfizer
ClassificationPrescription medicine
Ingredients / Active IngredientsSulfasalazine
Pack Size100s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage InstructionsStore below 30°C in a dry place, away from direct sunlight and out of reach of children.

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