Avexus 500mg Tablet

Rx
Brand Xepa
Manufacturer Xepa
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  • FDA Approved
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Avexus 500mg Tablet is a prescription-only medicine (POM) that contains Clarithromycin 500mg. It is supplied as a tablet and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, Avexus 500mg Tablet is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Take Avexus 500mg Tablet with or without food, swallowing the tablet whole with water. Space your doses evenly through the day, and complete the entire prescribed course even if you feel better before it is finished.

Dosage

The usual adult dose of Avexus 500mg Tablet is 250-500mg taken twice daily, depending on the infection being treated, as prescribed by your doctor. For H. pylori eradication, it is used together with other antibiotics and an acid-suppressing medicine as a combination regimen. Always complete the full course exactly as prescribed.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Nausea or vomiting
  • Diarrhea
  • Headache
  • Changes in taste
  • Stomach pain
  • Indigestion
  • Dizziness

Contraindications

  • Known hypersensitivity to clarithromycin or other macrolide antibiotics
  • Previous history of QT prolongation or cholestatic jaundice associated with clarithromycin use
  • Concurrent use with simvastatin or lovastatin, ergotamine/dihydroergotamine, or certain other medicines due to serious interaction risks
  • Concurrent use with colchicine in patients with kidney or liver impairment

Drug / Food Interactions

  • Statins metabolised by CYP3A4 (such as simvastatin and lovastatin) must not be combined with clarithromycin due to a significantly increased risk of severe muscle damage
  • Warfarin’s blood-thinning effect may be enhanced, requiring closer INR monitoring
  • Digoxin blood levels may increase when combined with clarithromycin
  • Carbamazepine and colchicine blood levels may increase, and ergot alkaloid medicines can cause severe blood vessel constriction when combined

Quick Tips

  • Complete the full course even if symptoms improve early
  • Tell your doctor about all other medicines you take, especially cholesterol-lowering statins
  • Report any irregular heartbeat or severe abdominal pain to your doctor promptly
  • A metallic or bitter taste is common and usually resolves after finishing treatment

Ingredients / Active Ingredients

  • Clarithromycin 500mg

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Frequently Asked Questions

Product Specifications

BrandXepa
ManufacturerXepa
ClassificationPrescription medicine
Ingredients / Active IngredientsClarithromycin
Pack Size10s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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