Bioflor 250mg Capsule

Bioflor 250mg Capsule contains Saccharomyces boulardii CNCM I-745, a freeze-dried probiotic yeast, at 250mg per capsule. This strain is one of the most widely studied yeast probiotics and is non-pathogenic in healthy individuals. Because it is a yeast rather than a bacterium, it is not affected by antibacterial medicines.

Each capsule is swallowed whole with a glass of water, making dosing simple and mess-free. The capsule is intended for adults and older children who are able to swallow capsules safely, while younger children are given the sachet form. The capsule may contain lactose as an excipient, which is relevant for people with lactose intolerance.

Bioflor 250mg Capsule is sold over the counter and is available through DoctorOnCall for delivery in Malaysia and Singapore. The capsule format is convenient for travel and for people who prefer not to prepare a powder. Customers are encouraged to read the leaflet, check the ingredient list and consult a pharmacist before use if they are unwell, immunocompromised or taking other medicines.

Take exactly as directed on the pack or as advised by a doctor or pharmacist.

1. Swallow the capsule whole with a glass of water, or open the capsule and mix the contents into a cool or lukewarm drink or soft food.
2. Do not take with very hot, iced or alcoholic drinks, as these can reduce the activity of the live yeast.
3. Capsules can be taken with or without meals.
4. Do not give capsules to children under 6 years because of the risk of choking; use the sachet form instead.

Do not use in people with a central venous catheter.

Adults and children over 6 years: The usual dose is 1 to 2 capsules (250mg to 500mg) per day, divided into one or two doses, unless your doctor or pharmacist advises otherwise.

Children under 6 years: Capsules are not suitable; ask a doctor or pharmacist about the sachet form.

Missed dose: Skip it and take the next dose at the usual time. Do not double the dose.

Do not exceed the dose stated on the pack. See a doctor if diarrhoea continues beyond 2 days or is accompanied by fever, blood in stools, vomiting or signs of dehydration.

Use before the expiry date printed on the packaging. Do not use capsules that are damaged or past the expiry date.

Store according to the storage instructions printed on the pack, in a dry place away from heat, moisture and direct sunlight. Keep the capsules in their original packaging and keep out of the reach of children.

• Common: Bloating, flatulence (wind) or mild abdominal discomfort.
• Common: Constipation in some people.
• Common: Increased thirst.
• Serious: Fungaemia (yeast entering the bloodstream), reported mainly in critically ill people or those with a central venous catheter, which causes fever and needs urgent care.
• Serious: Allergic reactions such as itching, rash, hives, swelling of the face or throat, or difficulty breathing, which need emergency medical help.

• Known hypersensitivity to Saccharomyces boulardii, to yeast, or to any ingredient in the capsule.
• People with a central venous catheter in place.
• Critically ill or seriously immunocompromised people, because of the risk of yeast entering the bloodstream.
• Children under 6 years, because of the choking risk with capsules.
• Known allergy to yeast products.

• Oral antifungal medicines may reduce the activity of the live yeast, so avoid combining them without medical advice.
• Do not take with alcohol, as alcohol can kill the live yeast and lower its activity.
• Antibacterial medicines do not affect the yeast, but tell your pharmacist about all the medicines you take.
• Avoid very hot or iced drinks and foods when taking the capsule contents, as temperature extremes may inactivate the yeast.
• People on immunosuppressive medicines should consult their doctor before use.

• Swallow the capsule with a full glass of water.
• Keep capsules in their original blister or bottle until you are ready to take them.
• Take at about the same times each day for a regular routine.
• Do not open capsules over a sink or work surface where other people may be exposed.
• Drink plenty of fluids throughout the day.
• Tell your pharmacist if you have a central line or weakened immunity.

Precautions: Do not use in people with a central venous catheter or in seriously immunocompromised or critically ill patients. Not suitable for children under 6 years because of choking risk. Check for lactose intolerance. Avoid very hot, iced or alcoholic drinks. Ask a doctor before use during pregnancy or breastfeeding, and in people taking immunosuppressants.

When to See a Doctor or Pharmacist: See a doctor if diarrhoea lasts more than 2 days, or if it comes with fever, blood or mucus in the stools, severe abdominal pain, persistent vomiting, or signs of dehydration such as dark urine, dizziness and very dry mouth. Older adults and people with weakened immunity should seek medical advice early.