Cholib 145/20mg Tablet
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Overview
Cholib 145/20mg Tablet is a fixed-dose combination tablet containing fenofibrate 145mg, a fibrate, and simvastatin 20mg, a statin, used to treat mixed dyslipidaemia – a pattern of high LDL (“bad”) cholesterol together with high triglycerides and/or low HDL (“good”) cholesterol – in patients who are not adequately controlled on a statin alone and for whom a fibrate-statin combination is considered appropriate by their doctor.
Simvastatin lowers LDL cholesterol by reducing its production in the liver, while fenofibrate mainly lowers triglycerides and raises HDL cholesterol. Combining the two addresses both sides of a mixed lipid problem more completely than either medicine alone.
How it Works
Simvastatin inhibits HMG-CoA reductase, the liver enzyme that controls cholesterol production, which lowers the liver’s own cholesterol output and increases its uptake of LDL cholesterol from the blood. Fenofibrate activates PPAR-alpha receptors, which increase the breakdown of triglyceride-rich particles and raise the production of HDL cholesterol, complementing simvastatin’s LDL-lowering effect for a more complete improvement in the overall lipid profile.
Directions for Use
Take Cholib 145/20mg Tablet in the evening with a meal, as food improves the absorption of fenofibrate. Swallow the tablet whole with water; do not crush or chew it. Try to take it at the same time each evening to build a consistent routine.
Dosage
The usual dose of Cholib 145/20mg Tablet is one tablet taken once daily in the evening. Your doctor will confirm the correct dose for you and will monitor your cholesterol, liver function, and muscle-related symptoms periodically with blood tests while you are on this combination.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Headache
- Stomach pain
- Nausea or vomiting
- Muscle pain or weakness
- Tiredness
- Skin rash or itching
- Mild diarrhea
Contraindications
- Known hypersensitivity to fenofibrate, simvastatin, or any ingredient in this product
- Active liver disease or unexplained persistent elevation of liver enzymes
- Severe kidney impairment
- Known gallbladder disease
- Pregnancy and breastfeeding
- Concomitant use with potent CYP3A4 inhibitors (e.g. itraconazole, ketoconazole, HIV protease inhibitors) or with ciclosporin or gemfibrozil, due to a significantly increased risk of myopathy and rhabdomyolysis
Drug / Food Interactions
- Potent CYP3A4 inhibitors (e.g. itraconazole, ketoconazole, clarithromycin, HIV protease inhibitors) significantly increase the risk of muscle-related side effects and must be avoided
- Other statins, fibrates, or ciclosporin further increase the risk of myopathy when combined
- Warfarin’s blood-thinning effect may be enhanced, requiring closer monitoring of clotting tests
- Large amounts of grapefruit juice can increase simvastatin levels in the blood
Quick Tips
- Report any unexplained muscle pain, tenderness, or weakness to your doctor promptly
- Attend all scheduled blood tests to monitor your cholesterol, liver function, and muscle enzymes
- Avoid large amounts of grapefruit juice while taking this medicine
- Take this medicine in the evening with food for the best absorption of fenofibrate
Frequently Asked Questions
What is Cholib 145/20mg Tablet used for?
Cholib 145/20mg Tablet is used to treat mixed dyslipidaemia – high LDL cholesterol together with high triglycerides and/or low HDL cholesterol – in patients whose lipid levels are not adequately controlled on a statin alone.
Why does this medicine combine a fibrate and a statin instead of using just one?
Simvastatin mainly lowers LDL cholesterol, while fenofibrate mainly lowers triglycerides and raises HDL cholesterol; combining them addresses a mixed lipid problem more completely than either medicine used alone, under close monitoring by your doctor.
What should I do if I develop muscle pain while taking this medicine?
Contact your doctor promptly, especially if the pain is accompanied by weakness, tenderness, fever, or dark urine, as this fibrate-statin combination carries a higher risk of muscle-related side effects than a statin alone.
Can I drink alcohol while taking this medicine?
It is best to limit alcohol intake, as both alcohol and this medicine are processed by the liver, and combining them may increase the risk of liver-related side effects.
What should I do if I miss a dose of Cholib 145/20mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue as normal. Do not double the dose.
Can I buy Cholib 145/20mg Tablet from DoctorOnCall?
Yes, Cholib 145/20mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Cholib 145/20mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Cholib 145/20mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Cholib 145/20mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Cholib 145/20mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Cholib 145/20mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Fenofibrate 145mg
- Simvastatin 20mg
Safety Advice
Pregnancy
This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.
Breastfeeding
This medicine is not safe during breastfeeding and should be avoided.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
No adequate data available. Consult a doctor before use.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
It is not advisable to drive if you experience side effects from this medicine.
Medical Review
