Combiwave SF 250 Pressured Inhalation
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Prescription Required
Overview
Combiwave SF 250 Pressured Inhalation is a prescription-only medicine (POM) presented as a medicine, with Salmeterol 25mcg (as salmeterol xinafoate) per actuation and Fluticasone propionate 250mcg per actuation as its active ingredient content.
This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.
Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.
Directions for Use
Shake Combiwave SF 250 Pressured Inhalation well before each use, breathe out fully, then form a tight seal around the mouthpiece and breathe in slowly and deeply while pressing down on the canister, holding your breath for about 10 seconds before breathing out. Rinse your mouth with water and spit it out after each use to reduce the risk of oral thrush and hoarseness, and use a spacer device if your doctor recommends one.
Dosage
The usual dose of Combiwave SF 250 Pressured Inhalation is 2 inhalations twice daily, morning and evening, though your doctor will determine the exact strength and number of inhalations based on the severity of your asthma or COPD. This inhaler is for regular, scheduled use only and must not be used for sudden breathlessness.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C, away from direct sunlight and out of reach of children. Do not puncture, break, or burn the canister even when it appears empty, and avoid exposing it to temperatures above 50°C, as the canister is pressurised.
Side Effects
- Headache
- Sore throat
- Hoarseness or voice changes
- Cough
- Nausea
- Fungal infection in the mouth (oral thrush)
- Mild muscle or bone pain
Contraindications
- Known hypersensitivity to salmeterol, fluticasone propionate, or any ingredient in this product
- Not for use as a reliever during an acute asthma attack or sudden worsening of symptoms
- Use with caution in patients with pulmonary tuberculosis or severe untreated respiratory infections
Drug / Food Interactions
- Strong CYP3A4 inhibitors (e.g. ketoconazole, ritonavir) can significantly increase fluticasone’s systemic absorption and side effects
- Beta-blockers (including some eye drops) may reduce salmeterol’s bronchodilating effect and should generally be avoided
- Other sympathomimetic medicines increase the risk of tremor and cardiovascular side effects
- Diuretics (e.g. furosemide) may worsen low blood potassium levels when combined with salmeterol
Quick Tips
- Use this inhaler regularly as prescribed, even when you feel well, as it is a preventer/maintenance treatment
- Always carry a separate fast-acting reliever inhaler for sudden symptoms
- Rinse your mouth with water after every use to prevent oral thrush and hoarseness
- Check the dose counter (if fitted) and replace the inhaler before it runs out
Frequently Asked Questions
Is Combiwave SF 250 Pressured Inhalation a prescription medicine?
Yes. Combiwave SF 250 Pressured Inhalation is a prescription-only medicine (POM). It can only be supplied against a valid prescription written by a registered doctor, and it should be used only by the person named on the prescription label.
What does Combiwave SF 250 Pressured Inhalation contain?
Combiwave SF 250 Pressured Inhalation is supplied as a medicine and contains Salmeterol 25mcg (as salmeterol xinafoate) per actuation and Fluticasone propionate 250mcg per actuation. The full composition is listed in the Composition section on this page and on the product packaging.
Why is there no information here about what Combiwave SF 250 Pressured Inhalation is for?
Malaysian rules for prescription medicines limit public product pages to product, safety and handling information. Your doctor decides whether this medicine is appropriate for you and will explain it during your consultation, and your pharmacist can answer further questions when the medicine is dispensed.
How should I take Combiwave SF 250 Pressured Inhalation?
Take it exactly as written on your prescription label. Do not increase, reduce or skip doses on your own, and do not continue beyond the period your doctor has prescribed. Practical handling steps are set out in the Directions for Use section on this page.
What should I do if I miss a dose?
Take it as soon as you remember, unless your next dose is nearly due. In that case skip the missed dose and carry on with your usual schedule. Never take two doses together to make up for a missed one. If you miss doses often, tell your doctor or pharmacist.
How should I store Combiwave SF 250 Pressured Inhalation?
Store below 30°C, away from direct sunlight and out of reach of children. Do not puncture, break, or burn the canister even when it appears empty, and avoid exposing it to temperatures above 50°C, as the canister is pressurised. Keep it in the original pack until use, and do not use it after the expiry date printed on the packaging.
What should I do if I notice side effects?
Tell your doctor or pharmacist about any reaction that concerns you, and seek medical care immediately for signs of a severe reaction such as difficulty breathing, swelling of the face, lips or throat, or a widespread rash. Reported reactions are listed in the Side Effects section on this page.
Can I stop taking Combiwave SF 250 Pressured Inhalation on my own?
No. Speak to your doctor before stopping, pausing or changing the dose, even if you feel well or think you no longer need the medicine.
How do I get a prescription for Combiwave SF 250 Pressured Inhalation?
Customers in Malaysia can complete an online consultation with a DoctorOnCall doctor, who decides whether a prescription is appropriate, or upload a valid prescription already issued by their own doctor.
Orders going to Singapore are dispatched from Malaysia as an international delivery, so you need to hold a valid prescription or doctor’s letter for the medicine. Check the consultation and prescription upload options shown at checkout for your delivery address before placing the order.
How long will delivery take?
Within Malaysia, standard delivery takes 3 to 5 working days. Same-day delivery is available in the Klang Valley for orders placed before 12pm; orders placed after 12pm arrive by the end of the next day.
Orders to Singapore are sent as international deliveries and take 5 to 9 working days. A lump-sum shipping and handling fee applies to every overseas delivery and is shown at checkout.
What payment methods can I use?
Customers in Malaysia can pay by FPX online banking, credit or debit card (Visa and Mastercard), and supported e-wallets including Touch ‘n Go eWallet, GrabPay and ShopeePay.
FPX and local e-wallets are tied to Malaysian bank and wallet accounts, so if your delivery address is in Singapore, use the payment options displayed at checkout for that address rather than assuming the same list applies.
Can Combiwave SF 250 Pressured Inhalation be delivered to Singapore?
Yes. DoctorOnCall ships to Singapore as an international order dispatched from Malaysia, arriving in 5 to 9 working days with a lump-sum shipping and handling fee.
Singapore’s Health Sciences Authority (HSA) allows personal imports of up to three months’ supply of a medicine for your own use or an immediate family member’s, as long as it contains no controlled drugs, psychotropic substances or prohibited items. Keep the product in its original labelled packaging and keep a copy of your prescription or doctor’s letter with it. Quantities above three months’ supply, and medicines containing controlled substances, require prior HSA approval.
Is Combiwave SF 250 Pressured Inhalation registered with the authorities?
Products listed on DoctorOnCall are registered with Malaysia’s Ministry of Health for supply in Malaysia, and each pack carries its MAL registration number.
An order delivered to Singapore arrives as a personal import of a Malaysia-registered product; HSA product registration is not required for personal-use quantities, but it is also not the same as a product registered for sale in Singapore. If you need a locally registered Singapore product, buy it from a pharmacy in Singapore.
Who do I contact if there is a problem with my order?
DoctorOnCall’s customer care team handles order, delivery and product queries through the contact channels on the site, including WhatsApp and the online help centre.
For deliveries to Singapore, allow more time before chasing an order than you would for a local Malaysian delivery, as the parcel passes through customs clearance and tracking updates can appear later in the journey.
Ingredients / Active Ingredients
- Salmeterol 25mcg (as salmeterol xinafoate) per actuation
- Fluticasone propionate 250mcg per actuation
Safety Advice
Pregnancy
This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.
Breastfeeding
Use with caution. Monitor infant for potential adverse reactions.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
Caution is advised when consuming alcohol with this medicine.
Driving
This medicine is generally safe and should not impair your driving ability.
