Cosyrel 5/5mg Tablet

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last updated:

Overview

Cosyrel 5/5mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Bisoprolol 5mg and Perindopril arginine 5mg as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Take Cosyrel 5/5mg Tablet once daily in the morning, before breakfast. Swallow the tablet whole with a glass of water. Do not stop taking this medicine suddenly without consulting your doctor – stopping a beta-blocker abruptly can trigger a rebound increase in heart rate, blood pressure, or chest pain, so any dose changes must be made gradually under medical supervision.

Dosage

Cosyrel 5/5mg Tablet is usually taken as one tablet once daily in the morning. It is intended for patients who are already stable on the individual components at matching doses; your doctor will confirm the appropriate strength for you. Always take this medicine exactly as prescribed.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Dizziness or lightheadedness
  • Cough
  • Headache
  • Tiredness or fatigue
  • Nausea
  • Low blood pressure
  • Rash or skin irritation
  • Elevated potassium levels
  • Changes in kidney function

Contraindications

  • Known hypersensitivity to bisoprolol, perindopril, or any other beta-blocker or ACE inhibitor
  • Severe bradycardia, second- or third-degree heart block (without a pacemaker), or decompensated heart failure
  • Severe asthma or severe chronic obstructive pulmonary disease (COPD)
  • Previous history of angioedema related to ACE inhibitor use
  • Pregnancy and breastfeeding

Drug / Food Interactions

  • Other heart-rate-lowering medicines (e.g. verapamil, diltiazem) may cause severe bradycardia or heart block when combined with bisoprolol
  • Potassium supplements or potassium-sparing diuretics may increase the risk of high blood potassium
  • Bisoprolol can mask the warning signs of low blood sugar (such as a fast heartbeat) in patients with diabetes taking insulin or other diabetes medicines
  • NSAIDs (e.g. ibuprofen) may reduce the blood-pressure-lowering effect and affect kidney function

Quick Tips

  • Take at the same time each morning, before breakfast, to build a consistent routine
  • Never stop this medicine abruptly – any changes must be made gradually under your doctor’s guidance
  • Check your pulse periodically if advised by your doctor, and report a very slow or irregular heartbeat
  • Inform your doctor if you have diabetes, as this medicine can mask signs of low blood sugar

Ingredients / Active Ingredients

  • Bisoprolol 5mg
  • Perindopril arginine 5mg

Safety Advice

Pregnancy

Not Advisable

Use during pregnancy is generally not recommended unless absolutely necessary.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Frequently Asked Questions

Product Specifications

BrandServier
ClassificationPrescription medicine
Ingredients / Active IngredientsPerindopril
Pack Size30s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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