Differin Cream

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Prescription Required

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Prescription required. Once back in stock, a doctor will review your prescription after payment.

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Overview

Differin Cream contains Adapalene 0.1% and is available as a cream. It is classified as a prescription medicine and may only be obtained with a valid prescription from a registered medical practitioner.

Only product, safety and handling information is published here. Anything beyond that is explained to you directly by your doctor or pharmacist as part of your consultation.

DoctorOnCall is a licensed online pharmacy. Orders for Differin Cream are processed only after a doctor has assessed your suitability and issued a prescription, and every order is checked by a registered pharmacist before it is sent out.

Directions for Use

Wash the affected area with a mild cleanser and pat completely dry before applying Differin Cream, as damp skin increases irritation. Use only a thin layer – a little covers a large area – and avoid the eyes, lips, nostrils, and any broken or sunburnt skin. Apply a broad-spectrum sunscreen during the day, as treated skin becomes more sensitive to sunlight.

Dosage

Apply a thin, pea-sized amount of Differin Cream once daily, usually in the evening, to the entire affected area of clean, dry skin – not just individual spots. Your doctor or pharmacist will advise how long to continue treatment, as visible improvement typically takes 4-12 weeks of regular use.

Side Effects

  • Skin dryness or flakiness
  • Redness or irritation
  • Mild burning or stinging sensation after application
  • Increased sensitivity to sunlight
  • Peeling of skin in the treated area

Contraindications

  • Known hypersensitivity to adapalene or any ingredient in this product
  • Application to eczematous, sunburnt, or broken skin
  • Pregnancy and breastfeeding, unless specifically advised by your doctor
  • Concurrent use with other strong topical exfoliants or peeling agents without medical advice

Drug / Food Interactions

  • Other topical retinoids, benzoyl peroxide at high strength, or salicylic acid products may increase skin irritation if used together without spacing them out
  • Medicated soaps, astringents, or alcohol-based cosmetics can worsen dryness and irritation
  • Waxing should be avoided on skin currently being treated, as it can tear irritated skin
  • Prolonged sun exposure or sunbed use increases the risk of sunburn on treated skin

Quick Tips

  • Start with a small pea-sized amount to gauge how your skin reacts
  • Use a fragrance-free, non-comedogenic moisturiser to manage dryness
  • Always apply sunscreen during the day while using this product
  • Be patient – visible acne improvement usually takes several weeks of consistent use

Ingredients / Active Ingredients

  • Adapalene 0.1%

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Generally Safe

Generally safe, but caution may be required in some patients.

Liver

Generally Safe

Generally safe, but caution may be required in some patients.

Alcohol

Generally Safe

Consuming alcohol with this medicine is generally safe, but moderate intake is advised.

Driving

Generally Safe

This medicine is generally safe and should not impair your driving ability.

Frequently Asked Questions

Product Specifications

BrandGalderma
ClassificationPrescription medicine
Ingredients / Active IngredientsAdapalene
Weight30g
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage InstructionsStore below 30°C in a dry place, away from direct sunlight and out of reach of children.

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