Duolin Respules

Duolin Respules is a prescription-only nebulizer solution containing a combination of Ipratropium Bromide, an anticholinergic bronchodilator, and Levosalbutamol, a short-acting beta-2 agonist bronchodilator. It is used for the relief of bronchospasm (narrowing of the airways) in conditions such as asthma and chronic obstructive pulmonary disease (COPD), particularly during acute exacerbations where rapid and effective opening of the airways is needed. This medicine is supplied as single-dose respules intended strictly for use with a nebulizer machine, not for oral or injectable use.

Because Duolin Respules combines two bronchodilators and is used to manage a potentially serious respiratory condition, it requires a doctor’s prescription or an online consultation with a doctor through DoctorOnCall before it can be dispensed. A doctor needs to confirm the diagnosis, assess the severity of the respiratory condition, and determine the appropriate nebulized dose and frequency, since inappropriate use of bronchodilators can mask worsening disease or cause cardiovascular side effects.

Ipratropium Bromide blocks acetylcholine receptors in the airway smooth muscle, reducing the reflex bronchoconstriction (tightening) that occurs in asthma and COPD, which helps widen the airways. Levosalbutamol is a beta-2 adrenergic agonist that relaxes the smooth muscle of the bronchi directly, producing rapid bronchodilation. When combined and administered via a nebulizer, these two mechanisms work together to more effectively relax and widen narrowed airways, improving airflow and easing breathing difficulty during an asthma or COPD flare-up.

Duolin Respules must only be used exactly as prescribed by a doctor following an online consultation through DoctorOnCall or an in-person assessment, and must be administered using a properly functioning nebulizer device — it is not to be swallowed or injected. Open one respule as directed, empty its full contents into the nebulizer chamber (diluting with saline if instructed by the doctor), and inhale the resulting mist through the mouthpiece or mask over the prescribed period. Do not reuse a partially used respule, and follow the doctor’s instructions on frequency and technique carefully.

The dose and frequency of Duolin Respules must be determined by a doctor based on the severity of the respiratory condition, following a prescription issued after an online consultation via DoctorOnCall or an in-person medical assessment. Patients should not increase the frequency of nebulization beyond what is prescribed, even if symptoms feel severe, and should seek urgent medical attention if breathing difficulty is not relieved or worsens despite treatment.

Duolin Respules should be used within the shelf-life period printed on the foil strip or carton, and discarded after the stated expiry date. Each respule is intended for single use only; any unused solution remaining in an opened respule should be discarded and not stored for later use.

Store Duolin Respules as directed on the packaging, typically at room temperature and protected from light, unless the label specifically instructs refrigeration. Keep respules in their original foil strip until ready for use to protect them from light and moisture, and keep out of the reach and sight of children.

• Known hypersensitivity to ipratropium bromide, levosalbutamol (or salbutamol/atropine-related compounds), or any other ingredient in this product
• Hypertrophic obstructive cardiomyopathy
• Tachyarrhythmia (abnormally fast, irregular heart rhythm)
• Not to be used without a doctor’s prescription and ongoing medical supervision
• Use with caution in patients with known cardiovascular disease, uncontrolled hyperthyroidism, or diabetes

• Should not generally be combined with other beta-blocker medicines, as they may reduce the bronchodilator effect of Levosalbutamol
• Concurrent use with other sympathomimetic bronchodilators may increase the risk of cardiovascular side effects
• Caution with monoamine oxidase inhibitors (MAOIs) or tricyclic antidepressants, which may increase cardiovascular effects
• Diuretics used together with this medicine may increase the risk of low blood potassium (hypokalaemia)
• Inform the prescribing doctor of all other respiratory or heart medicines being used before starting treatment

• Always obtain and use this medicine strictly under a doctor’s prescription and guidance via DoctorOnCall — never adjust the dose or frequency on your own
• Use only with a properly functioning nebulizer device as instructed by your doctor or pharmacist
• Seek urgent medical attention if breathing difficulty worsens or is not relieved after nebulization
• Report tremor, palpitations, or chest discomfort to the prescribing doctor promptly
• Attend scheduled doctor follow-up visits to monitor asthma/COPD control and adjust treatment as needed

Duolin Respules is intended for use with a nebulizer machine only and is typically prescribed for patients experiencing moderate to severe bronchospasm associated with asthma or COPD exacerbations. Ongoing doctor follow-up and monitoring are important parts of treatment with this medicine, as the underlying respiratory condition often requires a broader treatment plan beyond nebulized bronchodilators alone, including long-term controller medicines where appropriate.