Duopharma Vascor 40mg Tablet
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Overview
Duopharma Vascor 40mg Tablet contains simvastatin 40mg, a statin (HMG-CoA reductase inhibitor) used to lower high cholesterol and triglyceride levels and to reduce the risk of heart attack, stroke, and cardiovascular death. This product is manufactured by Duopharma, a Malaysian pharmaceutical company, under its own house brand name (note: distinct from the international bepridil brand also called Vascor).
Simvastatin works by blocking the liver enzyme responsible for producing cholesterol, which lowers LDL (“bad”) cholesterol and triglycerides while modestly raising HDL (“good”) cholesterol.
How it Works
Simvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in the liver’s cholesterol production pathway. As the liver produces less cholesterol, it increases the number of LDL receptors on its surface to pull more LDL cholesterol out of the bloodstream, lowering overall cholesterol levels. Because cholesterol synthesis in the liver is highest overnight, simvastatin is generally taken in the evening for the best effect.
Directions for Use
Take Duopharma Vascor 40mg Tablet once daily in the evening, with or without food. Swallow the tablet whole with water, and avoid grapefruit or grapefruit juice, as it can raise simvastatin levels in the blood. Continue taking it even if you feel well, since high cholesterol usually causes no symptoms.
Dosage
The usual starting dose of Duopharma Vascor 40mg Tablet is 10-20mg once daily in the evening, adjusted by your doctor based on your cholesterol response, up to a maximum that your doctor will determine based on your risk factors and other medicines. Your doctor will also arrange periodic cholesterol and liver function tests during treatment.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Headache
- Muscle pain or weakness
- Nausea or stomach discomfort
- Constipation
- Dizziness
- Elevated liver enzymes (in rare cases)
Contraindications
- Known hypersensitivity to simvastatin or any ingredient in this product
- Active liver disease or unexplained persistent elevation of liver enzymes
- Pregnancy and breastfeeding
- Concomitant use with strong CYP3A4 inhibitors such as itraconazole, ketoconazole, or certain HIV protease inhibitors
- Concomitant use with gemfibrozil or doses of simvastatin above 10mg with certain other interacting medicines, as advised by your doctor
Drug / Food Interactions
- Strong CYP3A4 inhibitors, such as itraconazole, ketoconazole, or clarithromycin, markedly raise simvastatin levels and increase the risk of muscle toxicity
- Grapefruit juice can increase simvastatin blood levels and should be avoided
- Gemfibrozil and other fibrates increase the risk of muscle-related side effects
- Warfarin’s blood-thinning effect may be enhanced, requiring closer INR monitoring
Quick Tips
- Take in the evening for the best cholesterol-lowering effect
- Avoid grapefruit and grapefruit juice while taking this medicine
- Report unexplained muscle pain, tenderness, or weakness to your doctor promptly
- Tell your doctor about all other medicines you take, as several interact significantly with simvastatin
Frequently Asked Questions
What is Duopharma Vascor 40mg Tablet used for?
Duopharma Vascor 40mg Tablet is used to lower high cholesterol and triglycerides and to reduce the risk of heart attack, stroke, and cardiovascular death in people with or at risk of cardiovascular disease.
Why should I take this medicine in the evening?
The liver produces most of its cholesterol overnight, so taking simvastatin in the evening lines up with this natural cycle and gives the best cholesterol-lowering effect.
Can I drink grapefruit juice while taking this medicine?
It is best to avoid grapefruit and grapefruit juice, as they can raise simvastatin levels in your blood and increase the risk of muscle-related side effects.
Why does my doctor ask about all my other medicines?
Simvastatin interacts significantly with several medicines, including certain antifungals and antibiotics, which can raise its blood levels and increase the risk of serious muscle problems.
What should I do if I miss a dose of Duopharma Vascor 40mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue as normal. Do not double the dose.
Can I buy Duopharma Vascor 40mg Tablet from DoctorOnCall?
Yes, Duopharma Vascor 40mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Duopharma Vascor 40mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Duopharma Vascor 40mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Duopharma Vascor 40mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Duopharma Vascor 40mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Duopharma Vascor 40mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Simvastatin 40mg
Safety Advice
Pregnancy
Use during pregnancy is generally not recommended unless absolutely necessary.
Breastfeeding
Generally not recommended while breastfeeding.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
Caution is advised when consuming alcohol with this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
