Estelle-35 Tablet

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last updated:

Overview

Estelle-35 Tablet is a prescription-only medicine (POM) presented as a tablet, with Cyproterone acetate 2mg and Ethinylestradiol 35mcg as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Take Estelle-35 Tablet at about the same time each day, with a full glass of water, following the order marked on the blister pack. If you miss a tablet, or have vomiting or severe diarrhoea, refer to the patient information leaflet or contact your doctor or pharmacist immediately for specific advice, as missing tablets can reduce contraceptive protection.

Dosage

Estelle-35 Tablet is usually taken as one tablet daily for 21 days, followed by a 7-day tablet-free interval, repeated in a monthly cycle. Your doctor may recommend continuing treatment for several menstrual cycles after your skin symptoms clear before reassessing whether to continue. Always follow your doctor’s specific instructions, as the dosing schedule and duration are individualised.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Nausea and headache
  • Breast tenderness
  • Mood changes
  • Breakthrough bleeding or spotting between periods, especially in the first few cycles
  • Serious: signs of a blood clot – calf pain, swelling or warmth in one leg, sudden chest pain or breathlessness, sudden severe headache, vision changes, or one-sided weakness – require emergency medical attention

Contraindications

  • Known hypersensitivity to cyproterone acetate, ethinylestradiol, or any ingredient in this product
  • Current or past history of venous or arterial thromboembolism, including deep vein thrombosis, pulmonary embolism, stroke, or heart attack
  • Migraine with aura
  • Smokers over the age of 35 (significantly increased risk of blood clots)
  • Known or suspected pregnancy, hormone-dependent cancers, or severe liver disease

Drug / Food Interactions

  • Enzyme-inducing medicines (e.g. certain anticonvulsants such as carbamazepine or phenytoin, rifampicin, St John’s Wort) can reduce this medicine’s effectiveness
  • Some antibiotics may occasionally reduce contraceptive reliability – ask your pharmacist if additional contraception is needed
  • Other hormonal medicines or hormonal contraceptives should not be taken at the same time
  • Smoking substantially increases the risk of serious blood clots and cardiovascular side effects with this medicine

Quick Tips

  • Never smoke while taking this medicine, particularly if you are over 35, due to a significantly increased risk of blood clots
  • This medicine is prescribed for your acne, hirsutism, seborrhoea, or contraceptive need – it should not be added on top of another contraceptive method
  • Take your tablet at the same time every day to maintain contraceptive protection
  • Report calf pain or swelling, chest pain, sudden severe headache, or vision changes to your doctor immediately
  • Attend regular follow-up appointments with your doctor to review ongoing treatment
  • Tell your doctor about your full medical and family history, especially any history of blood clots, before starting

Ingredients / Active Ingredients

  • Cyproterone acetate 2mg
  • Ethinylestradiol 35mcg

Safety Advice

Pregnancy

Not Safe

This medicine is not considered safe during pregnancy and should be avoided.

Breastfeeding

Not Advisable

Generally not recommended while breastfeeding.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

ClassificationPrescription medicine
Ingredients / Active IngredientsCyproterone
Pack Size21s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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