Isentress 400mg Tablet

Rx
Brand Cipla
Manufacturer Cipla
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Isentress 400mg Tablet is a prescription-only medicine (POM) that contains Raltegravir 400mg (as raltegravir potassium). It is supplied as a tablet and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, Isentress 400mg Tablet is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Take Isentress 400mg Tablet exactly as prescribed by your HIV specialist, at the same times each day, with or without food, as part of your full antiretroviral regimen. Do not skip, delay, or stop any of your medicines without first speaking to your specialist, as gaps in treatment can reduce its effectiveness and encourage drug-resistant virus to develop.

Dosage

Isentress 400mg Tablet is taken as part of a combination antiretroviral regimen individualised by your HIV specialist, who will determine the exact dose, frequency, and the other medicines to be combined with it based on your treatment history and viral resistance testing. Strict, consistent daily adherence is essential – never change your dose or regimen without your specialist’s guidance, as inconsistent use can allow the virus to develop resistance.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Headache
  • Trouble sleeping (insomnia)
  • Nausea
  • Tiredness or fatigue
  • Dizziness
  • Diarrhea
  • Abdominal pain
  • Rash (rarely serious but requires attention)

Contraindications

  • Known hypersensitivity to raltegravir or any ingredient in this product
  • Use only as part of a supervised combination antiretroviral regimen – never as a single agent or without specialist guidance

Drug / Food Interactions

  • Rifampicin significantly lowers raltegravir blood levels and requires a dose adjustment supervised by your specialist
  • Other strong inducers of drug-metabolising enzymes (e.g. certain anticonvulsants, St John’s Wort) may also reduce raltegravir levels
  • Aluminium- or magnesium-containing antacids can reduce raltegravir absorption – your specialist may advise spacing doses apart
  • Always tell your HIV specialist about every other prescription, over-the-counter, or herbal product you take, as interactions with antiretroviral regimens can be complex

Quick Tips

  • Take every dose of your full regimen at the same times daily – consistent adherence is essential to keep the virus suppressed
  • Never stop, skip, or change your antiretroviral regimen without speaking to your HIV specialist first
  • Attend all scheduled clinic visits and blood tests to monitor your viral load, immune status, and treatment response
  • Tell your specialist about any new medicines, including over-the-counter or herbal products, before starting them
  • Contact your doctor immediately if you experience unexplained muscle symptoms, a severe rash, or fever
  • Continue safer-sex and other prevention practices as advised by your specialist, as treatment lowers but does not eliminate transmission risk

Ingredients / Active Ingredients

  • Raltegravir 400mg (as raltegravir potassium)

Safety Advice

Pregnancy

Limited Data

Limited information is available regarding use during pregnancy. Use only if clearly needed.

Breastfeeding

Not Advisable

Generally not recommended while breastfeeding.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Frequently Asked Questions

Product Specifications

BrandCipla
ManufacturerCipla
ClassificationPrescription medicine
Ingredients / Active IngredientsRaltegravir
Pack Size60s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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