Kaletra 200/50mg Tablet

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Brand AbbVie
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last reviewed on

Overview

Kaletra 200/50mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Lopinavir 200mg and Ritonavir 50mg as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Take Kaletra 200/50mg Tablet with or without food, at evenly spaced times about 12 hours apart, exactly as prescribed by your HIV specialist. Swallow the tablets whole – do not crush or chew them. Strict, consistent daily adherence is essential, as missed or irregular doses increase the risk of the virus becoming resistant to treatment.

Dosage

The usual adult dose of Kaletra 200/50mg Tablet is two tablets twice daily, taken as part of a combination antiretroviral regimen prescribed by your HIV specialist. Your doctor will determine your full regimen and monitor your response – never adjust the dose or regimen on your own.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Nausea or vomiting
  • Diarrhoea
  • Abdominal pain
  • Headache
  • Dizziness
  • Fatigue
  • Changes in taste
  • Increased cholesterol or triglyceride levels
  • Mouth or throat pain

Contraindications

  • Known hypersensitivity to lopinavir, ritonavir, or any ingredient in this product
  • Severe liver impairment
  • Concomitant use with medicines highly dependent on CYP3A4 for clearance where increased plasma concentrations are associated with serious or life-threatening reactions (e.g. certain ergot derivatives, certain sedatives, some antiarrhythmics) – your doctor and pharmacist will check your full medicine list before starting

Drug / Food Interactions

  • Ritonavir is a strong inhibitor of the CYP3A4 liver enzyme, so it can significantly increase blood levels of many other medicines processed by this pathway – this is one of the most extensive interaction profiles among HIV medicines and must be checked carefully with every new prescription
  • Certain statins (e.g. simvastatin, lovastatin) can reach dangerously high levels and are generally avoided in combination
  • Hormonal contraceptives may become less effective, so alternative or additional contraception may be needed
  • St John’s Wort and certain anti-seizure medicines can reduce lopinavir/ritonavir levels and should be avoided unless specifically approved by your doctor

Quick Tips

  • Take this medicine every day, at the same times, without missing doses, to keep the virus suppressed and reduce resistance risk
  • Always tell every doctor, dentist, or pharmacist that you are taking this medicine before they prescribe anything new, given its extensive interaction potential
  • Never start, stop, or change any other medicine, including over-the-counter products and herbal supplements, without checking with your HIV specialist first
  • Report persistent vomiting, severe abdominal pain, or yellowing of the skin/eyes promptly
  • Keep all scheduled HIV specialist appointments and blood tests to monitor your viral load and treatment response

Ingredients / Active Ingredients

  • Lopinavir 200mg
  • Ritonavir 50mg

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Not Advisable

Generally not recommended while breastfeeding.

Kidney

Limited Data

Limited data in kidney disease patients. Use only if necessary.

Liver

Limited Data

Limited data available in liver disease patients.

Alcohol

Limited Data

Limited data is available regarding the effects of alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandAbbVie
ClassificationPrescription medicine
Ingredients / Active IngredientsRitonavir
Pack Size120s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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