Moduride Amiloride HCI 5mg + HCT 50mg Tablet
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Overview
Moduride Amiloride HCI 5mg + HCT 50mg Tablet contains amiloride hydrochloride 5mg and hydrochlorothiazide 50mg, a fixed-dose combination of a potassium-sparing diuretic and a thiazide diuretic used to treat high blood pressure (hypertension) and fluid retention (oedema).
Hydrochlorothiazide increases the excretion of sodium, chloride, and water by blocking their reabsorption in the kidney’s distal tubule, lowering blood pressure and reducing fluid build-up, but this can also cause the kidneys to lose potassium. Amiloride blocks sodium channels further along the same tubule, which produces an additional mild diuretic effect while helping the body retain potassium, offsetting the potassium loss that hydrochlorothiazide alone would cause.
How it Works
Hydrochlorothiazide inhibits the sodium-chloride cotransporter in the distal convoluted tubule of the kidney, reducing sodium and water reabsorption and increasing urine output, which lowers blood pressure and reduces oedema. Amiloride blocks epithelial sodium channels further downstream in the collecting duct, adding a mild diuretic effect while reducing potassium excretion, balancing the potassium-wasting effect of the thiazide component.
Directions for Use
Take Moduride Amiloride HCI 5mg + HCT 50mg Tablet in the morning to reduce the need to urinate during the night, with food if it causes stomach upset. Swallow the tablet whole with a glass of water. Do not stop taking this medicine suddenly without consulting your doctor, as blood pressure control needs to be continuous.
Dosage
The usual adult dose of Moduride Amiloride HCI 5mg + HCT 50mg Tablet is one tablet once daily, usually taken in the morning, though your doctor may adjust the dose or frequency based on your blood pressure or fluid status and periodic blood tests. Always take it exactly as prescribed.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
Hydrochlorothiazide
- Dizziness or light-headedness
- Increased urination
- Headache
- Nausea or vomiting
- Muscle cramps or weakness
- Sensitivity to sunlight
Amiloride
- Nausea or upset stomach
- Headache or dizziness
- Increased potassium levels (hyperkalemia)
- Muscle cramps
- Fatigue or weakness
Contraindications
- Known hypersensitivity to amiloride, hydrochlorothiazide, or other sulfonamide-derived medicines
- High blood potassium (hyperkalaemia) or conditions predisposing to it
- Severe kidney impairment or anuria (inability to produce urine)
- Addison’s disease (adrenal insufficiency)
- Concurrent use with potassium supplements or other potassium-sparing diuretics unless specifically directed by your doctor
Drug / Food Interactions
- ACE inhibitors, ARBs, and potassium supplements increase the risk of dangerously high blood potassium when combined with amiloride
- NSAIDs (e.g. ibuprofen) can reduce the diuretic and blood-pressure-lowering effect and affect kidney function
- Lithium blood levels may rise, increasing the risk of lithium toxicity
- Other blood pressure medicines or alcohol may increase the risk of dizziness or low blood pressure
Quick Tips
- Take in the morning to avoid needing to urinate at night
- Attend your scheduled blood tests to monitor potassium and kidney function
- Do not take potassium supplements or salt substitutes containing potassium without your doctor’s advice
- Rise slowly from sitting or lying down to reduce dizziness
- Monitor your blood pressure regularly as advised by your doctor
- Do not stop this medicine abruptly without medical advice
Frequently Asked Questions
What is Moduride Amiloride HCI 5mg + HCT 50mg Tablet used for?
Moduride Amiloride HCI 5mg + HCT 50mg Tablet is used to treat high blood pressure and fluid retention, combining a thiazide diuretic with a potassium-sparing diuretic in one tablet.
Why does this medicine combine two different diuretics?
Hydrochlorothiazide alone can cause the body to lose too much potassium. Amiloride helps the body retain potassium, so combining the two provides an effective diuretic and blood-pressure-lowering effect while reducing the risk of low potassium.
Can I use a salt substitute while taking this medicine?
Many salt substitutes contain potassium chloride, which can raise your blood potassium to unsafe levels when combined with amiloride. Check with your doctor or pharmacist before using any salt substitute.
Why do I need regular blood tests while taking this medicine?
Your doctor will periodically check your blood potassium and kidney function, since both are affected by this medicine, to make sure your levels stay within a safe range.
What should I do if I miss a dose of Moduride Amiloride HCI 5mg + HCT 50mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy Moduride Amiloride HCI 5mg + HCT 50mg Tablet from DoctorOnCall?
Yes, Moduride Amiloride HCI 5mg + HCT 50mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Moduride Amiloride HCI 5mg + HCT 50mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Moduride Amiloride HCI 5mg + HCT 50mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Moduride Amiloride HCI 5mg + HCT 50mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Moduride Amiloride HCI 5mg + HCT 50mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Moduride Amiloride HCI 5mg + HCT 50mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Amiloride hydrochloride 5mg
- Hydrochlorothiazide 50mg
Safety Advice
Hydrochlorothiazide
Pregnancy
There is no adequate data on use during pregnancy. Consult a doctor before use.
Breastfeeding
Use with caution. Monitor infant for potential adverse reactions.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
It is not advisable to drive if you experience side effects from this medicine.
Amiloride
Pregnancy
This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.
Breastfeeding
Use with caution. Monitor infant for potential adverse reactions.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
