Nexium (Esomeprazole) 40mg Tablet

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Manufacturer AstraZeneca
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

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Overview

Nexium 40mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Esomeprazole 40mg (as esomeprazole magnesium trihydrate) as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Take Nexium 40mg Tablet once daily, at least one hour before a meal, swallowing the tablet whole with a glass of water. Do not crush, chew, or split the tablet, as this would destroy the coating that protects the medicine from stomach acid before it is absorbed.

Dosage

The usual adult dose of Nexium 40mg Tablet is one tablet once daily, though your doctor may adjust the dose and duration depending on the condition being treated – for example, H. pylori eradication regimens are typically shorter courses, while GERD maintenance treatment may continue for longer. Always follow your doctor’s specific instructions.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Headache
  • Diarrhoea or constipation
  • Abdominal pain
  • Nausea or vomiting
  • Bloating or gas
  • Dizziness
  • Dry mouth

Contraindications

  • Known hypersensitivity to esomeprazole or other proton pump inhibitors (including substituted benzimidazoles)
  • Concurrent use with nelfinavir, an HIV medicine that requires stomach acid for absorption

Drug / Food Interactions

  • Clopidogrel’s antiplatelet effect may be reduced when combined with esomeprazole, as both are metabolised via the CYP2C19 enzyme – discuss with your doctor if you take clopidogrel
  • Reduces absorption of medicines that require an acidic stomach environment, such as ketoconazole and atazanavir
  • Methotrexate blood levels may increase when combined with high-dose esomeprazole, particularly with high-dose methotrexate regimens
  • Digoxin absorption may be altered, and long-term use may reduce absorption of vitamin B12, calcium, and magnesium

Quick Tips

  • Take at least one hour before a meal for the most consistent acid-suppressing effect
  • Swallow the tablet whole – do not crush, chew, or split it
  • Report severe or persistent diarrhoea to your doctor, especially if it develops during or after treatment
  • Discuss any long-term use with your doctor, as prolonged PPI therapy is periodically reviewed
  • Inform your doctor if you are taking clopidogrel, methotrexate, or HIV medicines

Ingredients / Active Ingredients

  • Esomeprazole 40mg (as esomeprazole magnesium trihydrate)

Safety Advice

Pregnancy

No Data

There is no adequate data on use during pregnancy. Consult a doctor before use.

Breastfeeding

Limited Data

Limited data on excretion in breast milk. Consult a doctor before use.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

No Data

No data is available regarding the interaction of alcohol with this medicine.

Driving

Generally Safe

This medicine is generally safe and should not impair your driving ability.

Frequently Asked Questions

Product Specifications

BrandAstraZeneca
ManufacturerAstraZeneca
ClassificationPrescription medicine
Ingredients / Active IngredientsEsomeprazole
Pack Size14s, 14s x3
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

Customer Reviews

4.4 · 10 reviews
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    Kiran Kumar · Purchased: 14s

    Received my parcel safely. Good packaging and smooth service!

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    Order dibuat dengan mudah. Website pun nampak kemas and user-friendly.

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