Pepzen 5mg Tablet

Brand Prime
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Pepzen 5mg Tablet is an oral tablet containing Serratiopeptidase 5mg, a proteolytic (protein-digesting) enzyme, as its active ingredient. It is manufactured by Prime Pharmaceutical Sdn Bhd, a Malaysian pharmaceutical company, and has been sold in the Malaysian market as an oral enzyme tablet for a number of years.

The product is classified as an OTC (Over-the-Counter) oral medicine, meaning it can be purchased directly from a pharmacy without a doctor’s prescription. Serratiopeptidase-based tablets are typically formulated as enteric-coated tablets, a coating designed to help the tablet pass through the stomach before releasing its enzyme content further along the digestive tract, though the exact coating and excipients used in this specific brand should be confirmed against the printed package insert.

Pepzen 5mg Tablet is supplied in a 10-tablet strip pack, a compact format intended for a short course of use, and its 5mg strength is in line with other Malaysian serratiopeptidase brands sold at this same dose per tablet.

Directions for Use

Swallow the tablet whole with a full glass of plain water. Do not crush or chew the tablet, particularly if it carries an enteric coating, as this could affect how the enzyme is released and absorbed along the digestive tract. Follow the timing in relation to meals shown on the product packaging or as advised by your pharmacist or doctor, as enzyme tablets are often taken on an empty stomach or before meals depending on the specific brand’s labelling.

Dosage

The exact adult dosing schedule for Pepzen 5mg Tablet should be confirmed against the printed package insert or your pharmacist’s advice, as the precise NPRA-registered dosing text for this specific brand could not be independently verified in this research. As a general reference point, oral serratiopeptidase 5mg tablets in Malaysia are commonly taken as one tablet two to three times a day, and the maximum daily dose stated on the product packaging should never be exceeded. Do not continue self-treating and see a doctor or pharmacist if your symptoms do not improve within a few days, if they worsen, or if you experience persistent stomach upset, unusual bruising, or bleeding while taking this product. This product is not intended for use in children without medical advice.

Storage Instructions

Store Pepzen 5mg Tablet at room temperature below 30°C, away from direct sunlight and moisture. Keep the tablets in their original strip packaging until just before use to protect them from humidity, and store them out of the reach and sight of children.

Side Effects

  • Nausea
  • Stomach discomfort
  • Diarrhoea
  • Skin rashes
  • Loss of appetite
  • Mild headache

Contraindications

  • Known hypersensitivity or allergy to serratiopeptidase or any excipient in the tablet.
  • Significant bleeding disorders or uncontrolled coagulopathy, given the enzyme’s proteolytic activity.
  • Active peptic ulcer disease or a history of gastrointestinal bleeding, unless a doctor has advised otherwise.
  • Use in children below the age recommended on the product packaging without medical advice.
  • Use immediately before or after surgery without first informing your surgeon or doctor, given the theoretical effect on bleeding tendency.

Drug / Food Interactions

  • Taking Pepzen 5mg Tablet together with anticoagulant medicines such as warfarin, or antiplatelet medicines such as aspirin or clopidogrel, may theoretically increase the risk of bleeding or bruising, so tell your doctor or pharmacist about all medicines you are taking before starting this product.
  • Avoid taking other oral enzyme supplements or products containing serratiopeptidase, bromelain, or papain at the same time without medical advice, as this may duplicate the active ingredient and increase the risk of gastrointestinal side effects.
  • Food may affect how the enzyme is absorbed, so follow the specific timing in relation to meals stated on the product packaging or advised by your pharmacist.

Quick Tips

  • Swallow the tablet whole with a full glass of water rather than chewing or crushing it.
  • Take the tablet at roughly the same times each day to build a consistent routine.
  • Keep the tablets in their original strip until just before you take them to protect them from moisture.
  • Tell your pharmacist about any blood-thinning medicines you take before starting this product.
  • Do not double up on a missed dose — simply continue with your next scheduled dose.
  • Check the expiry date on the strip before each use.

Ingredients / Active Ingredients

  • Active ingredient: Serratiopeptidase 5mg per tablet, a proteolytic (protein-digesting) enzyme.
  • Manufactured by Prime Pharmaceutical Sdn Bhd, Malaysia.
  • Supplied as an oral tablet, commonly formulated with an enteric coating in this product class to help the enzyme survive passage through the stomach; the specific excipients used in this brand are not publicly disclosed and should be confirmed against the printed package insert.
  • Packed in a 10-tablet strip.

Safety Advice

Pregnancy

Not Advisable

Use during pregnancy is generally not recommended unless absolutely necessary.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Precautions: Tell your doctor or pharmacist about any bleeding disorders, upcoming surgery or dental procedures, or blood-thinning medicines before taking Pepzen 5mg Tablet, given the enzyme’s proteolytic activity. Pregnant or breastfeeding women, and parents considering this product for a child, should check with a doctor or pharmacist first. Swallow the tablet whole and follow the timing in relation to meals stated on the packaging, as this can affect how well the enzyme is absorbed.

When to See a Doctor or Pharmacist: Stop taking the product and seek medical advice if you notice unusual bruising, prolonged bleeding, yellowing of the skin or eyes, severe stomach pain, or signs of an allergic reaction such as facial swelling or difficulty breathing. Speak with a pharmacist if your symptoms do not improve within a few days of use, or if you are unsure whether this product is suitable for you.

Frequently Asked Questions

Product Specifications

BrandPrime
ClassificationNon-prescription
Ingredients / Active IngredientsSerratiopeptidase
Pack Size10s
Shelf LifeUse Pepzen 5mg Tablet before the expiry date printed on the strip and outer carton. Do not use the tablets past their stated expiry date, even if the strip appears intact.

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