Pletaal 100mg Tablet

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Brand Otsuka
Manufacturer Otsuka
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Pletaal 100mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Cilostazol 100mg as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Take Pletaal 100mg Tablet on an empty stomach, at least 30 minutes before or 2 hours after a meal, swallowing the tablet whole with water. Continue regular use as prescribed, as the improvement in walking distance builds up gradually over several weeks rather than appearing immediately.

Dosage

The usual adult dose of Pletaal 100mg Tablet is 100mg twice daily, taken at least 30 minutes before or 2 hours after meals, adjusted by your doctor based on your tolerability and any interacting medicines. The full benefit on walking distance may take several weeks of continuous use to become apparent.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Headache
  • Diarrhoea
  • Dizziness
  • Palpitations (feeling of rapid heartbeat)
  • Abnormal stool
  • Nausea
  • Fluid retention in ankles or feet

Contraindications

  • Heart failure of any severity – this is an important, well-documented contraindication specific to cilostazol and this drug class
  • Known hypersensitivity to cilostazol or any ingredient in this product
  • Active bleeding, such as an active peptic ulcer or a history of intracranial haemorrhage
  • Severe hepatic or renal impairment

Drug / Food Interactions

  • CYP3A4/CYP2C19 inhibitors (e.g. omeprazole, diltiazem, erythromycin, ketoconazole) can increase cilostazol blood levels, and a dose reduction may be needed
  • Other antiplatelet medicines or anticoagulants (aspirin, clopidogrel, warfarin) increase the risk of bleeding when combined
  • Grapefruit juice may increase cilostazol levels through the same metabolic pathway
  • Inform your doctor of all medicines you are taking, given the significant potential for drug interactions with this medicine

Quick Tips

  • Take on an empty stomach for consistent absorption
  • Be patient – the full improvement in walking distance can take up to several weeks of continuous use to appear
  • Report any new or worsening shortness of breath, or swelling of the legs/ankles, to your doctor immediately, given the heart failure risk associated with this medicine class
  • Avoid grapefruit juice while taking this medicine

Ingredients / Active Ingredients

  • Cilostazol 100mg

Safety Advice

Pregnancy

Not Advisable

Use during pregnancy is generally not recommended unless absolutely necessary.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Safe If Prescribed

Use only if prescribed, with possible monitoring.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandOtsuka
ManufacturerOtsuka
ClassificationPrescription medicine
Ingredients / Active IngredientsCilostazol
Pack Size100s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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