Premarin 0.625mg Tablet

Brand Pfizer
Manufacturer Viatris
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

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Overview

Premarin 0.625mg Tablet is supplied as a tablet, with Conjugated Estrogens 0.625mg. It is supplied in a pack size of 28s.

No prescription is required for this product, as it is a non-prescription medicine. This page is limited to product, safety and handling information.

If you would like guidance before buying, you can speak to a doctor or pharmacist through an online consultation on DoctorOnCall. Orders are dispensed by a registered pharmacist and delivered to your address.

Directions for Use

Take Premarin exactly as prescribed by your doctor, usually as one tablet daily, swallowed whole with water, at around the same time each day. If your uterus is still intact, your doctor will usually prescribe this together with a progestogen to protect the lining of the womb; do not omit the progestogen component of your regimen unless instructed. Do not stop treatment abruptly without discussing it with your doctor.

Dosage

The dose is individualised based on your symptoms, medical history, and response to treatment; 0.625mg is this is the higher/standard of the two commonly available oral premarin strengths (the other being 300mcg), commonly used as a standard starting dose for menopausal symptom relief. Your doctor will periodically review whether you still need treatment and will aim for the lowest effective dose for the shortest duration needed to control symptoms. If you miss a dose, take it as soon as you remember on the same day; do not double up the next day’s dose.

Storage Instructions

Store below 30°C in a dry place away from direct sunlight and moisture, in the original packaging to protect the tablets from light. Keep out of the reach and sight of children.

Side Effects

  • Breast tenderness or pain
  • Headache or migraine
  • Nausea or bloating
  • Mood swings or depression
  • Vaginal spotting or discharge
  • Swelling in hands or feet
  • Increased risk of blood clots (rare)

Contraindications

  • Undiagnosed abnormal vaginal bleeding
  • Known, suspected, or past history of breast cancer or other estrogen-dependent cancer
  • Current or past history of blood clots in the veins (deep vein thrombosis, pulmonary embolism)
  • Current or recent arterial thromboembolic disease such as stroke or heart attack
  • Active liver disease or significantly impaired liver function
  • Known or suspected pregnancy
  • Known hypersensitivity to conjugated estrogens or any ingredient in the tablet

Drug / Food Interactions

  • Enzyme-inducing medicines such as rifampicin or certain anticonvulsants (e.g. phenytoin, carbamazepine), which can reduce estrogen’s effectiveness
  • St John’s Wort, which may reduce the effectiveness of estrogen therapy
  • Thyroid hormone replacement, as estrogen can affect thyroid-binding proteins and may require dose adjustment
  • Anticoagulant (blood-thinning) medicines, as estrogen can alter clotting factors
  • Grapefruit juice, which may increase blood levels of estrogen
  • Corticosteroids, as estrogen may alter how they are metabolised in the body

Quick Tips

  • Take your tablet at the same time each day to help maintain steady hormone levels
  • Attend regular follow-up visits so your doctor can reassess whether you still need HRT
  • Keep up with routine breast examinations and mammograms as advised by your doctor
  • Avoid smoking while on estrogen therapy, as it increases the risk of blood clots
  • Report any unexpected or heavy vaginal bleeding to your doctor promptly
  • Seek urgent care for symptoms of a blood clot such as leg swelling, pain, sudden chest pain, or breathlessness

Ingredients / Active Ingredients

  • Conjugated Estrogens 0.625mg
  • Lactose and other tablet binders
  • Magnesium stearate
  • Film coating agents

Safety Advice

Pregnancy

Not Safe

This medicine is not considered safe during pregnancy and should be avoided.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Not Advisable

Not recommended in patients with liver disease.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Generally Safe

This medicine is generally safe and should not impair your driving ability.

Relevant Information

Premarin 0.625mg Tablet is a systemic (oral) form of hormone replacement therapy and works throughout the body, which is different from Premarin 0.625% Vaginal Cream, a local estrogen treatment applied directly to the vagina mainly for vaginal dryness and atrophy with less systemic absorption. Your doctor will help decide which form and strength of estrogen therapy suits your symptoms, and HRT is generally reviewed regularly to use the lowest effective dose for the shortest time needed.

Frequently Asked Questions

Product Specifications

BrandPfizer
ManufacturerViatris
ClassificationNon-prescription
Ingredients / Active IngredientsConjugated Estrogens
Pack Size28s
Shelf LifePremarin tablets remain stable until the expiry date printed on the packaging when stored correctly and kept in their original blister/container. Do not use the tablets after the expiry date.

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Important Medical Information

💊 Recommended Dosage:

The dose is individualised based on your symptoms, medical history, and response to treatment; 0.625mg is this is the higher/standard of the two commonly available oral premarin strengths (the other being 300mcg), commonly used as a standard starting dose for menopausal symptom relief. Your doctor will periodically review whether you still need treatment and will aim for the lowest effective dose for the shortest duration needed to control symptoms. If you miss a dose, take it as soon as you remember on the same day; do not double up the next day’s dose.

🛑 Contraindications (Do not use if):
  • Undiagnosed abnormal vaginal bleeding
  • Known, suspected, or past history of breast cancer or other estrogen-dependent cancer
  • Current or past history of blood clots in the veins (deep vein thrombosis, pulmonary embolism)
  • Current or recent arterial thromboembolic disease such as stroke or heart attack
  • Active liver disease or significantly impaired liver function
  • Known or suspected pregnancy
  • Known hypersensitivity to conjugated estrogens or any ingredient in the tablet
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
  • Breast tenderness or pain
  • Headache or migraine
  • Nausea or bloating
  • Mood swings or depression
  • Vaginal spotting or discharge
  • Swelling in hands or feet
  • Increased risk of blood clots (rare)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.