Prograf 1mg Capsule
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Prescription Required
Overview
Prograf 1mg Capsule contains tacrolimus 1mg, a calcineurin-inhibitor immunosuppressant medicine. It is used, under transplant specialist supervision, to prevent the body’s immune system from rejecting a transplanted organ (such as a kidney, liver, or heart), and is sometimes used to treat rejection that has not responded to other treatments. Tacrolimus is usually combined with other immunosuppressive medicines as part of a specialist-directed regimen.
Tacrolimus binds to a protein called FKBP-12 inside immune cells; the resulting complex blocks the enzyme calcineurin, which normally activates T-lymphocytes (a type of white blood cell central to organ rejection). By inhibiting calcineurin, tacrolimus reduces T-cell activation and the production of interleukin-2, dampening the immune response that would otherwise attack the transplanted organ.
How it Works
By forming a complex with FKBP-12 that inhibits calcineurin, tacrolimus prevents the activation and proliferation of T-lymphocytes and reduces production of interleukin-2 and other cytokines. This suppresses the immune response that would otherwise recognise and attack a transplanted organ as foreign tissue.
Directions for Use
Take Prograf 1mg Capsule consistently, generally on an empty stomach (at least 1 hour before or 2-3 hours after a meal) at the same times each day, as instructed by your transplant team, since food can affect how much is absorbed. Swallow the capsule whole with water. Do not switch between brands or generic versions of tacrolimus without your doctor’s explicit instruction, as tacrolimus has a narrow therapeutic index and different products may not be interchangeable at the same dose.
Dosage
The dose of Prograf 1mg Capsule is highly individualised by your transplant specialist based on the type of organ transplanted, your kidney and liver function, other medicines you take, and – most importantly – regular blood trough-level monitoring, since tacrolimus has a narrow therapeutic index (a small difference between an effective dose and a toxic one). Never adjust your dose without your transplant team’s explicit instruction.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Headache
- Nausea or vomiting
- Increased blood sugar levels
- Risk of infections
- Tremors or shakiness
- High blood pressure
- Fatigue or weakness
- Skin irritation (with topical use)
Contraindications
- Known hypersensitivity to tacrolimus or any ingredient in this product
- Use only under the supervision of a transplant specialist experienced in immunosuppressive therapy
- Caution in pregnancy and breastfeeding – only used if the specialist determines the benefit outweighs the risk
- Concurrent use with cyclosporine is not recommended without specialist guidance
Drug / Food Interactions
- Grapefruit and grapefruit juice significantly increase tacrolimus blood levels and must be avoided
- Strong CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, diltiazem) can raise tacrolimus levels, increasing toxicity risk
- Strong CYP3A4 inducers (e.g. rifampicin, St John’s Wort) can lower tacrolimus levels, risking transplant rejection
- Live vaccines should generally be avoided while on tacrolimus – discuss any vaccination with your transplant team first
Quick Tips
- Never miss a scheduled blood trough-level or kidney function test – these are mandatory for safe use of this medicine
- Never switch between brands or generic versions of tacrolimus without your transplant specialist’s explicit approval
- Strictly avoid grapefruit and grapefruit juice
- Report any signs of infection to your transplant team promptly, as immunosuppression increases infection risk
- Use sun protection, as long-term immunosuppression increases the risk of skin cancer
Frequently Asked Questions
What is Prograf 1mg Capsule used for?
Prograf 1mg Capsule is an immunosuppressant medicine used mainly to prevent rejection after an organ transplant. It works by dampening the part of your immune system that would otherwise attack the new organ, and must be used under the ongoing supervision of your transplant specialist.
Why do I need regular blood tests while taking this medicine?
Tacrolimus has a narrow therapeutic index, meaning the difference between a dose that is effective and one that is toxic is small. Regular blood trough-level and kidney function tests allow your transplant team to keep your dose in the safe, effective range.
Can I switch to a different brand or generic version of tacrolimus?
Only if your transplant specialist explicitly instructs you to. Because of tacrolimus’s narrow therapeutic index, switching brands or generics without specialist guidance and follow-up monitoring can lead to under- or over-immunosuppression.
Can I eat grapefruit while taking this medicine?
No. Grapefruit and grapefruit juice can significantly raise tacrolimus blood levels and increase the risk of side effects, so they should be avoided completely.
What should I do if I miss a dose of Prograf 1mg Capsule?
Contact your transplant team for specific guidance, as missed-dose handling can vary by individual regimen. Do not simply double your next dose without checking with your care team first.
Why do I feel more prone to infections while on this medicine?
Tacrolimus works by suppressing your immune system to protect your transplanted organ, which also reduces your ability to fight off infections. Report fever, chills, or any signs of infection to your transplant team promptly.
Can I buy Prograf 1mg Capsule from DoctorOnCall?
Yes, Prograf 1mg Capsule is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Prograf 1mg Capsule according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Prograf 1mg Capsule?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Prograf 1mg Capsule cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Prograf 1mg Capsule?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Prograf 1mg Capsule?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Tacrolimus 1mg
Safety Advice
Pregnancy
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
Generally not recommended while breastfeeding.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
It is not advisable to drive if you experience side effects from this medicine.
Medical Review
