Sandimmun Neoral 100mg Capsule

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last updated:

Overview

Sandimmun Neoral 100mg Capsule is a prescription-only medicine (POM) presented as a capsule, with Ciclosporin 100mg (microemulsion formulation) as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Take Sandimmun Neoral 100mg Capsule at the same time(s) each day, and consistently either always with food or always without food, exactly as your doctor instructs, as switching can change how much medicine your body absorbs. Do not switch between different ciclosporin brands or formulations without your specialist’s explicit direction, as they are not automatically interchangeable. Attend every scheduled blood test appointment so your doctor can monitor your ciclosporin level, kidney function and blood pressure.

Dosage

The dose of Sandimmun Neoral 100mg Capsule is highly individualised by your transplant or specialist physician, based on your body weight, the organ transplanted or condition being treated, and regular measurement of your ciclosporin blood (trough) levels. There is no standard fixed dose – your doctor will adjust your dose based on blood test results, kidney function, and clinical response, so never change your dose without specialist guidance.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • High blood pressure
  • Increased hair growth
  • Kidney problems
  • Headache
  • Nausea
  • Swollen gums
  • Tremors
  • Fatigue

Contraindications

  • Known hypersensitivity to ciclosporin or any ingredient in this product
  • Uncontrolled high blood pressure
  • Uncontrolled active infections
  • Active malignancy (other than certain skin cancers being treated)
  • Concomitant use with St John’s Wort (reduces ciclosporin levels significantly)

Drug / Food Interactions

  • Grapefruit juice significantly increases ciclosporin blood levels and must be avoided
  • Azole antifungals and certain macrolide antibiotics (e.g. ketoconazole, erythromycin) increase ciclosporin levels and toxicity risk
  • Rifampicin and St John’s Wort reduce ciclosporin levels, risking transplant rejection or disease flare
  • NSAIDs, aminoglycoside antibiotics, and potassium-sparing diuretics increase the risk of kidney impairment or high blood potassium when combined with ciclosporin

Quick Tips

  • Never miss a scheduled blood test – ciclosporin blood levels must be monitored closely to keep the dose safe and effective
  • Never switch ciclosporin brands or formulations without your specialist’s approval
  • Avoid grapefruit and grapefruit juice completely while on this medicine
  • Report any signs of infection, fever, or unusual bleeding to your care team immediately
  • Avoid live vaccines while taking this medicine unless specifically approved by your specialist
  • Attend regular blood pressure and kidney function checks as scheduled

Ingredients / Active Ingredients

  • Ciclosporin 100mg (microemulsion formulation)

Safety Advice

Pregnancy

Safe If Prescribed

This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

BrandNovartis
ClassificationPrescription medicine
Ingredients / Active IngredientsCyclosporine
Pack Size50s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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