Sybrava 284mg/1.5 ml Pre-Filled Syringe
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Overview
Sybrava 284mg/1.5ml Pre-Filled Syringe contains inclisiran, a small interfering RNA (siRNA) therapy given as a subcutaneous injection by a healthcare professional, used together with diet and statin therapy to lower LDL cholesterol (“bad” cholesterol) in adults with primary hyperlipidaemia who need additional cholesterol lowering.
Inclisiran works by targeting the liver’s production of PCSK9, a protein that normally breaks down LDL receptors. By reducing PCSK9 production, more LDL receptors remain available on liver cells to clear LDL cholesterol from the blood, lowering LDL-C levels.
How it Works
Inclisiran uses RNA interference technology to bind to and silence the messenger RNA that liver cells use to produce PCSK9 protein. With less PCSK9 produced, LDL receptors on liver cells are not broken down as quickly, so more receptors remain available to remove LDL cholesterol from the bloodstream.
Directions for Use
This medicine is administered only by a doctor or nurse as a subcutaneous injection, usually into the abdomen; it is not self-administered at home. Continue any statin or other cholesterol medicine as prescribed alongside this treatment.
Dosage
The regimen is a subcutaneous injection given by a healthcare professional at the start of treatment, again three months later, and then once every six months thereafter; the treating doctor confirms this schedule is appropriate alongside your other lipid-lowering therapy.
Shelf Life
Refer to the expiry date printed on the packaging; this medicine is stored and administered only by healthcare professionals.
Storage Instructions
Stored under controlled, refrigerated conditions by the pharmacy or clinic as specified by the manufacturer; not intended for home storage.
Side Effects
- Injection site reactions – redness, pain, or swelling
- Joint pain (arthralgia)
- Urinary tract infection
- Diarrhoea
- Bronchitis or upper respiratory infection symptoms
Contraindications
- Known hypersensitivity to inclisiran or any ingredient in the formulation
- Pregnancy and breastfeeding, unless specifically directed by the treating doctor
Drug / Food Interactions
- No major drug-drug interactions have been identified, as inclisiran is not metabolised through the liver enzyme pathways that many other medicines use.
- It is intended to be used alongside statins and other standard lipid-lowering therapy, not as a replacement for them.
- Inform your doctor of all medicines and supplements you are taking.
Quick Tips
- Keep every scheduled injection appointment, as the twice-yearly maintenance schedule depends on consistent timing.
- Continue your statin or other prescribed cholesterol medicine alongside this treatment unless your doctor advises otherwise.
- Report persistent injection site reactions to your care team.
- Attend scheduled cholesterol level checks so your doctor can assess your response to treatment.
Frequently Asked Questions
What is Sybrava 284mg/1.5ml used for?
It is used together with diet and statin therapy to further lower LDL (“bad”) cholesterol in adults who need additional cholesterol control.
How is this different from a statin?
It works through a different mechanism – silencing the liver’s production of a protein called PCSK9 – and is given by injection only twice a year after the initial doses, rather than as a daily tablet.
How often will I need this injection?
The schedule is an initial dose, a second dose three months later, and then once every six months thereafter.
Can I give myself this injection at home?
No, it must be given by a doctor or nurse as a subcutaneous injection.
Do I still need to take my statin?
Yes, this medicine is used alongside statin therapy, not as a replacement for it, unless your doctor specifically advises otherwise.
What are the common side effects?
Injection site reactions such as redness or pain are the most common; joint pain and urinary tract infections have also been reported.
Will I need blood tests during treatment?
Yes, your doctor will check your cholesterol levels periodically to assess how well the treatment is working.
Can I buy Sybrava 284mg/1.5 ml Pre-Filled Syringe from DoctorOnCall?
Yes, Sybrava 284mg/1.5 ml Pre-Filled Syringe is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Sybrava 284mg/1.5 ml Pre-Filled Syringe according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Sybrava 284mg/1.5 ml Pre-Filled Syringe?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Sybrava 284mg/1.5 ml Pre-Filled Syringe cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Sybrava 284mg/1.5 ml Pre-Filled Syringe?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Sybrava 284mg/1.5 ml Pre-Filled Syringe?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Inclisiran (sodium) 284mg/1.5ml
Medical Review
