Aprovasc 300/10mg Tablet

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Chong Zhan Pong
Written byDr. Chong Zhan PongDoctor of Medicine (MD), International Medical University (IMU)

Last updated:

Overview

Aprovasc 300/10mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Irbesartan 300mg and Amlodipine 10mg (as amlodipine besilate) as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Take Aprovasc 300/10mg Tablet at the same time every day, with or without food, swallowing the tablet whole with water. Continue taking it even if your blood pressure normalises, and do not stop suddenly without consulting your doctor, as blood pressure control needs to be continuous.

Dosage

The usual dose of Aprovasc 300/10mg Tablet is one tablet once daily. Your doctor will determine the appropriate strength (300mg irbesartan / 10mg amlodipine) based on your blood pressure response and tolerability, often after monotherapy with either component alone has not achieved your target blood pressure.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Dizziness or lightheadedness, especially when standing up
  • Fatigue or tiredness
  • Nausea
  • Headache
  • High potassium levels (may show as muscle weakness or irregular heartbeat)
  • Back pain

Contraindications

  • Known hypersensitivity to irbesartan, amlodipine, or any ingredient in this product
  • Pregnancy (ARBs can harm the developing baby, especially in the second and third trimester)
  • Severe hepatic impairment
  • Severe aortic stenosis or cardiogenic shock
  • Concomitant use with aliskiren in patients with diabetes or kidney impairment

Drug / Food Interactions

  • Potassium supplements or potassium-sparing diuretics may increase the risk of high blood potassium
  • NSAIDs (e.g. ibuprofen) may reduce the blood-pressure-lowering effect and affect kidney function
  • Strong CYP3A4 inhibitors (e.g. ketoconazole, ritonavir) may increase amlodipine blood levels
  • Simvastatin – amlodipine may increase simvastatin levels, so a dose limit applies

Quick Tips

  • Monitor your blood pressure regularly as advised by your doctor
  • Rise slowly from sitting or lying down to reduce dizziness
  • Report significant swelling of the ankles or legs to your doctor
  • Do not stop this medicine abruptly without medical advice, and inform your doctor before starting any new supplement, especially potassium

Ingredients / Active Ingredients

  • Irbesartan 300mg
  • Amlodipine 10mg (as amlodipine besilate)

Safety Advice

Pregnancy

Not Safe

This medicine is not considered safe during pregnancy and should be avoided.

Breastfeeding

Limited Data

Limited data on excretion in breast milk. Consult a doctor before use.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Frequently Asked Questions

Product Specifications

BrandSanofi-Aventis
ClassificationPrescription medicine
Ingredients / Active IngredientsIrbesartan
Pack Size28s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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