Aprovasc 300/10mg Tablet
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Overview
Aprovasc 300/10mg Tablet contains irbesartan 300mg combined with amlodipine 10mg, a fixed-dose combination of an angiotensin II receptor blocker (ARB) and a calcium channel blocker used to treat high blood pressure (hypertension), typically when a single medicine alone has not adequately controlled blood pressure.
Irbesartan blocks the action of angiotensin II, a hormone that narrows blood vessels, while amlodipine relaxes blood vessels by blocking calcium entry into vascular smooth muscle. Together, these two complementary actions lower blood pressure more than either medicine alone.
How it Works
Irbesartan selectively blocks the AT1 receptor, preventing angiotensin II from causing blood vessel narrowing and sodium retention. Amlodipine blocks L-type calcium channels in vascular smooth muscle cells, reducing calcium influx and causing the blood vessels to relax and widen. The combined effect produces a greater and more consistent reduction in blood pressure.
Directions for Use
Take Aprovasc 300/10mg Tablet at the same time every day, with or without food, swallowing the tablet whole with water. Continue taking it even if your blood pressure normalises, and do not stop suddenly without consulting your doctor, as blood pressure control needs to be continuous.
Dosage
The usual dose of Aprovasc 300/10mg Tablet is one tablet once daily. Your doctor will determine the appropriate strength (300mg irbesartan / 10mg amlodipine) based on your blood pressure response and tolerability, often after monotherapy with either component alone has not achieved your target blood pressure.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Dizziness or lightheadedness, especially when standing up
- Fatigue or tiredness
- Nausea
- Headache
- High potassium levels (may show as muscle weakness or irregular heartbeat)
- Back pain
Contraindications
- Known hypersensitivity to irbesartan, amlodipine, or any ingredient in this product
- Pregnancy (ARBs can harm the developing baby, especially in the second and third trimester)
- Severe hepatic impairment
- Severe aortic stenosis or cardiogenic shock
- Concomitant use with aliskiren in patients with diabetes or kidney impairment
Drug / Food Interactions
- Potassium supplements or potassium-sparing diuretics may increase the risk of high blood potassium
- NSAIDs (e.g. ibuprofen) may reduce the blood-pressure-lowering effect and affect kidney function
- Strong CYP3A4 inhibitors (e.g. ketoconazole, ritonavir) may increase amlodipine blood levels
- Simvastatin – amlodipine may increase simvastatin levels, so a dose limit applies
Quick Tips
- Monitor your blood pressure regularly as advised by your doctor
- Rise slowly from sitting or lying down to reduce dizziness
- Report significant swelling of the ankles or legs to your doctor
- Do not stop this medicine abruptly without medical advice, and inform your doctor before starting any new supplement, especially potassium
Frequently Asked Questions
What is Aprovasc 300/10mg Tablet used for?
Aprovasc 300/10mg Tablet is a combination medicine used to treat high blood pressure, usually when a single blood pressure medicine has not been enough to control it on its own.
Why does this tablet combine two different blood pressure medicines?
Irbesartan and amlodipine lower blood pressure through different, complementary mechanisms. Combining them in one tablet often controls blood pressure more effectively than either medicine alone, while keeping to a simple once-daily dose.
Can I stop taking this medicine once my blood pressure is normal?
No, do not stop without consulting your doctor. High blood pressure often has no symptoms, and stopping suddenly can cause it to rise again.
Why do my ankles sometimes swell with this medicine?
Ankle or leg swelling is a recognised side effect of the amlodipine component. It is usually not serious, but let your doctor know if the swelling is significant or bothersome.
What should I do if I miss a dose of Aprovasc 300/10mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy Aprovasc 300/10mg Tablet from DoctorOnCall?
Yes, Aprovasc 300/10mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Aprovasc 300/10mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Aprovasc 300/10mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Aprovasc 300/10mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Aprovasc 300/10mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Aprovasc 300/10mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Irbesartan 300mg
- Amlodipine 10mg (as amlodipine besilate)
Safety Advice
Pregnancy
This medicine is not considered safe during pregnancy and should be avoided.
Breastfeeding
Limited data on excretion in breast milk. Consult a doctor before use.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
It is not advisable to drive if you experience side effects from this medicine.
Medical Review
