Alcon Simbrinza 10mg/ml Eye Drop
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Overview
Alcon Simbrinza 10mg/ml Eye Drop is a combination eye drop containing brinzolamide 10mg/ml, a carbonic anhydrase inhibitor, and brimonidine, an alpha-2 adrenergic agonist, used together to lower elevated intraocular pressure in open-angle glaucoma or ocular hypertension.
Brinzolamide reduces the production of aqueous humour by blocking an enzyme involved in its formation, while brimonidine both reduces production and increases outflow of this fluid; together they provide a greater pressure-lowering effect than either ingredient used alone.
How it Works
Brinzolamide inhibits carbonic anhydrase II in the ciliary body, reducing bicarbonate and fluid secretion into the eye, while brimonidine stimulates alpha-2 receptors to decrease aqueous humour formation and enhance uveoscleral outflow. The combined dual mechanism lowers intraocular pressure more effectively than a single-agent drop.
Directions for Use
Shake Alcon Simbrinza 10mg/ml Eye Drop well before use. Tilt your head back, pull down the lower eyelid to form a pocket, and instil one drop without letting the tip touch your eye. Press gently on the inner corner of the eye for about a minute after instillation, and wait at least 5 minutes before using any other eye drop.
Dosage
The usual dose of Alcon Simbrinza 10mg/ml Eye Drop is one drop in the affected eye(s) three times daily, as instructed by your eye doctor, evenly spaced through the day for consistent pressure control.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
Brimonidine
- Eye redness or irritation
- Blurred vision
- Dry eyes
- Fatigue or drowsiness
- Headache
- Mild stinging or burning sensation in the eyes
- Sensitivity to light
Brinzolamide
- Blurred vision
- Eye discomfort or stinging
- Bitter taste in the mouth
- Dry eyes
- Headache
- Sensitivity to light
- Redness of the eye
- Feeling like something is in your eye
Contraindications
- Known hypersensitivity to brinzolamide, brimonidine, or sulfonamide-derived medicines
- Severe kidney impairment
- Infants and young children (brimonidine component carries a risk of central nervous system depression)
- Concurrent use with monoamine oxidase inhibitors (MAOIs)
Drug / Food Interactions
- High-dose salicylates (aspirin) may interact with the carbonic anhydrase inhibitor component
- Other sulfonamide-derived medicines may have additive effects or increase the risk of sensitivity reactions
- CNS depressants (alcohol, sedatives) may increase drowsiness from the brimonidine component
- MAOIs may affect the metabolism of brimonidine and should be discussed with your doctor
Quick Tips
- Shake the bottle well before every use, as this is a suspension
- Wait at least 5 minutes before using a different eye drop
- Vision may be temporarily blurred right after use – avoid driving or operating machinery until it clears
- Press on the inner corner of your eye after each drop to reduce absorption into the bloodstream
Frequently Asked Questions
What is Alcon Simbrinza 10mg/ml Eye Drop used for?
Alcon Simbrinza 10mg/ml Eye Drop is a combination eye drop used to lower elevated eye pressure in glaucoma or ocular hypertension when a single medicine does not provide enough control.
Why do I need to shake the bottle before using this eye drop?
This eye drop is a suspension, meaning the active ingredients can settle at the bottom of the bottle. Shaking it well before each use ensures you get an even, effective dose.
Why does this eye drop leave a bitter taste in my mouth?
A small amount of the eye drop can drain through your tear duct into the back of your throat, where the brinzolamide component can produce a bitter or metallic taste. This is a known, usually harmless effect.
Can I drive right after using this eye drop?
Your vision may be temporarily blurred immediately after instillation, so you should wait until your vision clears before driving or operating machinery.
What should I do if I miss a dose of Alcon Simbrinza 10mg/ml Eye Drop?
Use the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not use a double dose.
Can I buy Alcon Simbrinza 10mg/ml Eye Drop from DoctorOnCall?
Yes, Alcon Simbrinza 10mg/ml Eye Drop is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Alcon Simbrinza 10mg/ml Eye Drop according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Alcon Simbrinza 10mg/ml Eye Drop?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Alcon Simbrinza 10mg/ml Eye Drop cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Alcon Simbrinza 10mg/ml Eye Drop?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Alcon Simbrinza 10mg/ml Eye Drop?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Brinzolamide 10mg/ml
- Brimonidine tartrate 2mg/ml
Safety Advice
Brimonidine
Pregnancy
This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.
Breastfeeding
Limited data on excretion in breast milk. Consult a doctor before use.
Kidney
Use cautiously. Dose adjustment or monitoring may be required.
Liver
Limited data available in liver disease patients.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
It is not advisable to drive if you experience side effects from this medicine.
Brinzolamide
Pregnancy
This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.
Breastfeeding
Limited data on excretion in breast milk. Consult a doctor before use.
Kidney
Not generally recommended in patients with kidney disease.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
Caution is advised when consuming alcohol with this medicine.
Driving
It is not advisable to drive if you experience side effects from this medicine.
Medical Review
