Anprodryl Syrup

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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Anprodryl Syrup is a prescription-only medicine (POM) presented as a syrup, with Ammonium Chloride and Diphenhydramine Hydrochloride as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Shake the bottle well before each use and measure the dose accurately using the cup or spoon provided with {title_en} – do not use a regular household spoon, as this can lead to an inaccurate dose. Take it with or after food if it causes stomach upset, and avoid taking it close to bedtime driving or other tasks requiring alertness due to its sedating effect.

Dosage

The dose of Anprodryl Syrup depends on age and body weight, and your doctor or pharmacist will advise the correct dose and dosing interval for you or your child using the measuring device provided. Do not exceed the recommended dose or duration without medical advice.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

Ammonium Chloride + Diphenhydramine

  • Drowsiness or dizziness
  • Dry mouth or throat
  • Nausea or stomach upset
  • Headache
  • Blurred vision
  • Mild constipation

Ammonium Chloride

  • Nausea or vomiting
  • Abdominal discomfort
  • Headache
  • Fatigue or weakness
  • Irritability or confusion (with high doses)
  • Metabolic acidosis (in rare or prolonged cases)

Contraindications

  • Known hypersensitivity to ammonium chloride, diphenhydramine, or any ingredient in this product
  • Severe liver or kidney impairment
  • Narrow-angle glaucoma or significant urinary retention (due to the antihistamine’s anticholinergic effect)
  • Use in combination with other sedating antihistamines or cough/cold products containing similar ingredients

Drug / Food Interactions

  • Alcohol and other sedating medicines (e.g. sleeping tablets, some pain relievers) increase drowsiness and impair coordination
  • MAOIs may prolong and intensify the antihistamine’s anticholinergic effects
  • Other cough, cold, or allergy products often contain overlapping ingredients – check labels to avoid accidental double-dosing
  • Sodium bicarbonate and other alkalinising agents may reduce the effectiveness of ammonium chloride

Quick Tips

  • Always use the measuring device provided rather than a household spoon
  • Avoid driving or operating machinery after taking this syrup, as it can cause drowsiness
  • Avoid alcohol while taking this medicine
  • Check other cough, cold, or allergy medicines you are using to avoid duplicating antihistamine or expectorant ingredients

Ingredients / Active Ingredients

  • Ammonium Chloride
  • Diphenhydramine Hydrochloride

Safety Advice

Ammonium Chloride + Diphenhydramine

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Use With Care

Use cautiously. Dose adjustment or monitoring may be required.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Ammonium Chloride

Pregnancy

Safe If Prescribed

This medicine should only be used during pregnancy if prescribed by a doctor after careful evaluation.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Not Advisable

Not generally recommended in patients with kidney disease.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Use With Care

Caution is advised when consuming alcohol with this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Frequently Asked Questions

Product Specifications

ClassificationPrescription medicine
Ingredients / Active IngredientsAmmonium Chloride + Diphenhydramine, Ammonium Chloride
Volume100ml
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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Important Medical Information

💊 Recommended Dosage:

The dose of Anprodryl Syrup depends on age and body weight, and your doctor or pharmacist will advise the correct dose and dosing interval for you or your child using the measuring device provided. Do not exceed the recommended dose or duration without medical advice.

🛑 Contraindications (Do not use if):
  • Known hypersensitivity to ammonium chloride, diphenhydramine, or any ingredient in this product
  • Severe liver or kidney impairment
  • Narrow-angle glaucoma or significant urinary retention (due to the antihistamine’s anticholinergic effect)
  • Use in combination with other sedating antihistamines or cough/cold products containing similar ingredients
If you are unsure, please chat with us or consult your doctor.
⚠️ Common Side Effects:
Ammonium Chloride + Diphenhydramine:
  • Drowsiness or dizziness
  • Dry mouth or throat
  • Nausea or stomach upset
  • Headache
  • Blurred vision
  • Mild constipation
Ammonium Chloride:
  • Nausea or vomiting
  • Abdominal discomfort
  • Headache
  • Fatigue or weakness
  • Irritability or confusion (with high doses)
  • Metabolic acidosis (in rare or prolonged cases)
Stop taking this medication immediately and consult your doctor if you experience severe allergic reactions or side effects.
IMPORTANT: Unsure? Chat with our pharmacists (Mon - Sat, 9:00am - 6:00pm) before buying.