Entresto 50mg Tablet

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Manufacturer Novartis
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Entresto 50mg Tablet is a prescription-only medicine (POM) presented as a tablet, with Sacubitril 24mg and Valsartan 26mg as its active ingredient content.

This page is limited to product, safety and handling information, in line with Malaysian rules on prescription medicine information for the public. Your prescriber or pharmacist is the right source for anything beyond that, together with the leaflet inside the pack.

Through DoctorOnCall, this product is supplied after an online consultation with a licensed doctor and a valid prescription, and it is checked by a registered pharmacist before dispensing. Take it exactly as prescribed, and speak to your doctor before stopping, changing the dose, or starting any other medicine alongside it.

Directions for Use

Take Entresto 50mg Tablet twice daily, at about the same times each day, with or without food. Swallow the tablet whole with a glass of water. Do not stop or change your dose without consulting your doctor, as heart failure requires continuous treatment.

Dosage

Entresto 50mg Tablet (50mg) is typically the recommended starting dose, particularly for patients switching from an ACE inhibitor or at higher risk of low blood pressure, which your doctor may increase over time as tolerated. Your doctor will usually increase your dose gradually, generally every 2-4 weeks as tolerated, up to your target maintenance dose, based on your blood pressure, kidney function, and potassium levels. If you are switching from an ACE inhibitor, treatment with this medicine must not start until at least 36 hours after your last dose of the ACE inhibitor, due to an increased risk of angioedema if the two overlap.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Dizziness or lightheadedness
  • Fatigue
  • Headache
  • Cold or flu-like symptoms
  • Diarrhea
  • Back pain
  • Low blood pressure
  • Elevated potassium levels

Contraindications

  • Known hypersensitivity to sacubitril, valsartan, or any ingredient in this product
  • History of angioedema related to previous ACE inhibitor or angiotensin receptor blocker (ARB) use
  • Concomitant use with an ACE inhibitor – these must never be taken together, and a washout of at least 36 hours is required when switching between the two, due to an increased risk of angioedema
  • Concomitant use with aliskiren in patients with diabetes or renal impairment
  • Pregnancy

Drug / Food Interactions

  • ACE inhibitors must not be combined with this medicine – a 36-hour washout period is required when switching, due to the risk of angioedema
  • Potassium supplements or potassium-sparing diuretics can increase the risk of high blood potassium
  • NSAIDs may reduce this medicine’s effectiveness and can worsen kidney function
  • Lithium levels may increase when combined with this medicine, raising the risk of lithium toxicity

Quick Tips

  • Never take this medicine together with an ACE inhibitor – tell your doctor about all your current medicines before starting
  • Monitor your blood pressure regularly and report dizziness or fainting to your doctor
  • Attend scheduled blood tests for kidney function and potassium levels
  • Rise slowly from sitting or lying down to reduce dizziness
  • Seek emergency care immediately for any swelling of the face, lips, tongue, or throat, or difficulty breathing
  • Do not stop this medicine abruptly without medical advice, as heart failure requires continuous treatment

Ingredients / Active Ingredients

  • Sacubitril 24mg
  • Valsartan 26mg

Safety Advice

Pregnancy

No Data

There is no adequate data on use during pregnancy. Consult a doctor before use.

Breastfeeding

Limited Data

Limited data on excretion in breast milk. Consult a doctor before use.

Kidney

No Data

No adequate data available. Consult a doctor before use.

Liver

Not Advisable

Not recommended in patients with liver disease.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Not Advisable

It is not advisable to drive if you experience side effects from this medicine.

Frequently Asked Questions

Product Specifications

BrandNovartis
ManufacturerNovartis
ClassificationPrescription medicine
Ingredients / Active IngredientsValsartan
Pack Size30s
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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