Epiduo Gel

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Manufacturer Galderma
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Epiduo Gel is a prescription-only medicine (POM) that contains Adapalene 0.1% and Benzoyl peroxide 2.5%. It is supplied as a gel and is dispensed in Malaysia only against a valid prescription issued by a registered doctor.

Under Malaysian rules for prescription medicines, this page carries product, safety and handling information only. Your doctor or pharmacist will explain whether this medicine is suitable for you, the dose you should take, and how long you should take it.

On DoctorOnCall, Epiduo Gel is reviewed by a licensed doctor through an online consultation and dispensed by a registered pharmacist before delivery. Always follow the instructions on your prescription label and the package insert supplied with the product, and do not share this medicine with anyone else.

Directions for Use

Wash and gently dry the affected skin before application. Apply a pea-sized amount thinly and evenly over the entire affected area (not just individual spots), avoiding the eyes, lips, and mucous membranes. Wash your hands after use. Apply a broad-spectrum sunscreen during the day, as this medicine increases your skin’s sensitivity to sunlight.

Dosage

Apply a thin layer of Epiduo Gel to the affected area once daily, usually in the evening. Your doctor may advise starting with application every other day if your skin is sensitive, before building up to once-daily use as tolerated.

Storage Instructions

Store below 30°C in a dry place, away from direct sunlight and out of reach of children.

Side Effects

  • Dryness or peeling of the skin
  • Redness or irritation
  • Burning or stinging sensation
  • Skin flaking
  • Mild allergic reactions such as itching or rash

Contraindications

  • Known hypersensitivity to adapalene, benzoyl peroxide, or any ingredient in this product
  • Pregnancy (topical retinoids are generally avoided in pregnancy – discuss with your doctor)
  • Use on eczema, sunburnt, or broken/irritated skin
  • Concurrent use with other strong irritant or peeling skin products unless specifically advised by your doctor

Drug / Food Interactions

  • Other topical acne treatments, retinoids, or exfoliants used at the same time may increase skin irritation – space these out or avoid combining unless advised by your doctor
  • Sun exposure and sunbeds increase the risk of sunburn during treatment – always use sunscreen
  • Benzoyl peroxide is an oxidising agent that can bleach hair and coloured fabric on contact – avoid contact with hair, clothing, and bedding
  • Other topical products containing salicylic acid or alcohol-based astringents may worsen dryness or irritation when used together

Quick Tips

  • Start with application every other night if you are new to retinoids, to help your skin build tolerance
  • Moisturise regularly with a non-comedogenic moisturiser to manage dryness
  • Always apply sunscreen during the day, as this medicine increases sun sensitivity
  • Avoid contact with towels, pillowcases, and clothing, as benzoyl peroxide can bleach coloured fabric
  • Avoid applying near the eyes, lips, and mucous membranes
  • Give the medicine 8-12 weeks of consistent use for the full effect before judging results – do not stop early

Ingredients / Active Ingredients

  • Adapalene 0.1%
  • Benzoyl peroxide 2.5%

Safety Advice

Pregnancy

Generally Safe

This medicine is generally safe during pregnancy, though minor risks may exist in rare cases.

Breastfeeding

Generally Safe

This medicine is generally safe during breastfeeding with minimal risk to the infant.

Kidney

No Data

No adequate data available. Consult a doctor before use.

Liver

Limited Data

Limited data available in liver disease patients.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Generally Safe

This medicine is generally safe and should not impair your driving ability.

Frequently Asked Questions

Product Specifications

BrandGalderma
ManufacturerGalderma
ClassificationPrescription medicine
Ingredients / Active IngredientsBenzoyl Peroxide
Weight15g
Shelf LifeUse this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.

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