Exforge HCT 10/160/12.5mg Tablet

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Manufacturer Novartis
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Dr. Mohd Izzat Amir Bin Awang
Reviewed byDr. Mohd Izzat Amir Bin AwangDoctor of Medicine (MD), University of Mansoura - Manchester
Dr. Adeline Carol Peters
Written byDr. Adeline Carol PetersBachelor of Medicine and Bachelor of Surgery (MBBS) — Manipal Academy of Higher Education (MAHE)

Last updated:

Overview

Exforge HCT 10/160/12.5mg Tablet contains Amlodipine 10mg (as amlodipine besylate), Valsartan 160mg and Hydrochlorothiazide 12.5mg and is available as a tablet. It is classified as a prescription medicine and may only be obtained with a valid prescription from a registered medical practitioner.

Only product, safety and handling information is published here. Anything beyond that is explained to you directly by your doctor or pharmacist as part of your consultation.

DoctorOnCall is a licensed online pharmacy. Orders for Exforge HCT 10/160/12.5mg Tablet are processed only after a doctor has assessed your suitability and issued a prescription, and every order is checked by a registered pharmacist before it is sent out.

Directions for Use

Take Exforge HCT exactly as prescribed by your doctor, generally once daily at the same time each day, with or without food, and swallow the tablet whole with water. Do not adjust the dose or stop the medicine on your own, as abrupt discontinuation can cause blood pressure to rebound; any dose changes should only be made after a follow-up review with your prescribing doctor.

Dosage

The dosage is individualised by the prescribing doctor based on prior response to dual therapy (amlodipine/valsartan or valsartan/hydrochlorothiazide) and is not intended as a first-line starting treatment. Regular blood pressure checks and periodic blood tests for kidney function and electrolytes (particularly potassium and sodium) are recommended while on this combination, and only a doctor should adjust the strength if blood pressure remains high or if side effects occur.

Storage Instructions

Store below 30°C in a dry place away from direct sunlight and moisture, and keep the tablets in their original blister packaging until just before use to protect them from humidity. Keep out of reach of children.

Side Effects

  • Headache
  • Dizziness or lightheadedness
  • Swelling of the ankles or feet
  • Fatigue
  • Flushing (warmth or redness in face/skin)
  • Nausea

Contraindications

  • Known hypersensitivity to amlodipine, valsartan, hydrochlorothiazide, other sulfonamide-derived drugs, or any component of the tablet
  • Pregnancy or planning pregnancy — angiotensin receptor blockers can harm the unborn baby, especially in the second and third trimesters
  • Severe kidney impairment or anuria (inability to pass urine)
  • Severe liver impairment or biliary obstruction
  • Uncontrolled low potassium, low sodium, or high calcium levels that have not been corrected
  • Severe, uncorrected low blood pressure

Drug / Food Interactions

  • Other blood pressure medicines or nitrates may increase the risk of excessive blood pressure drops
  • NSAIDs (such as ibuprofen or diclofenac) taken regularly may reduce the blood-pressure-lowering effect and increase the risk of kidney problems
  • Potassium supplements, potassium-sparing diuretics, or salt substitutes containing potassium may raise blood potassium to unsafe levels
  • Lithium levels in the blood may rise when taken with this combination, requiring closer monitoring
  • Grapefruit juice may increase amlodipine levels in some individuals and is best avoided or limited
  • Alcohol can intensify dizziness and low blood pressure effects

Quick Tips

  • Attend all scheduled follow-up appointments so your doctor can monitor blood pressure, kidney function, and electrolyte levels
  • Rise slowly from sitting or lying positions to reduce dizziness, particularly when starting treatment
  • Do not stop this medicine suddenly without medical advice, even if you feel well
  • Tell your doctor about all other medicines and supplements you are taking, including over-the-counter painkillers
  • Report unusual muscle weakness, cramping, or persistent dizziness to your doctor promptly, as these may signal an electrolyte imbalance

Ingredients / Active Ingredients

  • Amlodipine besylate (equivalent to amlodipine 10mg) — calcium channel blocker
  • Valsartan 160mg — angiotensin II receptor blocker
  • Hydrochlorothiazide 12.5mg — thiazide diuretic
  • Standard tablet excipients
  • Amlodipine 10mg (as amlodipine besylate)
  • Valsartan 160mg
  • Hydrochlorothiazide 12.5mg

Safety Advice

Pregnancy

Use With Care

This medicine should be used cautiously during pregnancy. Monitoring may be required.

Breastfeeding

Use With Care

Use with caution. Monitor infant for potential adverse reactions.

Kidney

Generally Safe

Generally safe, but caution may be required in some patients.

Liver

Use With Care

Use cautiously. Liver function monitoring may be required.

Alcohol

Not Advisable

It is not advisable to consume alcohol while taking this medicine.

Driving

Use With Care

Use caution while driving until you know how this medicine affects you.

Relevant Information

Exforge HCT is reserved for patients whose hypertension has proven difficult to control on two-drug regimens, and its triple mechanism means it is not typically used as an initial treatment for newly diagnosed high blood pressure. Because it combines a diuretic with two other blood-pressure-lowering agents, ongoing monitoring of kidney function and electrolytes is an important part of safe long-term use, and any dose or regimen changes should always go through the prescribing doctor.

Frequently Asked Questions

Product Specifications

BrandNovartis
ManufacturerNovartis
ClassificationPrescription medicine
Ingredients / Active IngredientsAmlodipine
Pack Size28s, 7s
Shelf LifeExforge HCT tablets are typically stable for up to 36 months from the date of manufacture when stored unopened in original packaging; always check the expiry date printed on the blister or carton before use.

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