Exforge HCT 5/160/12.5mg Tablet
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Overview
Exforge HCT 5/160/12.5mg Tablet contains amlodipine, valsartan, and hydrochlorothiazide 5/160/12.5mg, a fixed-dose triple combination used to treat high blood pressure (hypertension) in patients whose blood pressure is not adequately controlled by a two-drug combination or who are already stable on the three components taken separately.
Each component lowers blood pressure by a different mechanism: amlodipine relaxes blood vessels by blocking calcium channels, valsartan blocks the blood-vessel-narrowing hormone angiotensin II, and hydrochlorothiazide reduces fluid volume by increasing salt and water excretion. Together, these three complementary actions provide comprehensive blood pressure control.
How it Works
Amlodipine blocks L-type calcium channels in vascular smooth muscle, causing vasodilation; valsartan blocks the AT1 receptor, preventing angiotensin II from constricting blood vessels and promoting sodium retention; hydrochlorothiazide inhibits sodium-chloride reabsorption in the distal renal tubule, increasing salt and water excretion. Acting together, they reduce vascular resistance and circulating fluid volume through three distinct pathways.
Directions for Use
Take Exforge HCT 5/160/12.5mg Tablet at about the same time every day, with or without food. Swallow the tablet whole with a glass of water. Do not stop taking this medicine suddenly, even if you feel well, as blood pressure control needs to be continuous.
Dosage
Exforge HCT 5/160/12.5mg Tablet is usually taken once daily, with the specific strength prescribed by your doctor based on your blood pressure control on the individual components or on dual combinations. This medicine is generally reserved for patients who have already been assessed as needing all three agents together.
Shelf Life
Use this product before the expiry date stated on the packaging. Do not use the medicine if the expiry date has passed.
Storage Instructions
Store below 30°C in a dry place, away from direct sunlight and out of reach of children.
Side Effects
- Headache
- Dizziness or lightheadedness
- Swelling of the ankles or feet
- Fatigue
- Flushing (warmth or redness in face/skin)
- Nausea
Contraindications
- Known hypersensitivity to amlodipine, valsartan, hydrochlorothiazide, other sulfonamide-derived drugs, or any ingredient in this product
- Pregnancy (can cause harm to the developing baby, especially in the second and third trimester)
- Severe liver impairment, biliary obstruction, or anuria
- Severe hypotension, unstable haemodynamic status, or shock
- Concomitant use with aliskiren in patients with diabetes or kidney impairment
Drug / Food Interactions
- Potassium supplements or potassium-sparing diuretics may increase the risk of high blood potassium
- NSAIDs (e.g. ibuprofen) may reduce the blood-pressure-lowering effect and affect kidney function
- Grapefruit and grapefruit juice may increase amlodipine levels and side effects
- Lithium levels may rise, and other blood-pressure-lowering medicines or alcohol may increase the risk of low blood pressure
Quick Tips
- Take at the same time each day to build a consistent routine
- Monitor your blood pressure regularly as advised by your doctor
- Rise slowly from sitting or lying down to reduce dizziness
- Attend scheduled blood tests to check kidney function and electrolyte levels
Frequently Asked Questions
What is Exforge HCT 5/160/12.5mg Tablet used for?
Exforge HCT 5/160/12.5mg Tablet is used to treat high blood pressure that requires three complementary medicines working together, usually after your doctor has established that a two-drug combination is not sufficient.
Why do I need three blood pressure medicines in one tablet?
Combining three mechanisms – a calcium channel blocker, an ARB, and a diuretic – can achieve blood pressure control that a single medicine or a two-drug combination cannot, while keeping to one daily tablet.
Can I stop taking this medicine if my blood pressure normalises?
No, do not stop without consulting your doctor. Normal readings show the medicine is working, not that treatment can be stopped, and doing so can cause blood pressure to rise again.
Will this medicine make me urinate more often?
Yes, the hydrochlorothiazide component increases urine output, especially in the first few weeks. Tell your doctor if this is troublesome or associated with dizziness.
What should I do if I miss a dose of Exforge HCT 5/160/12.5mg Tablet?
Take the missed dose as soon as you remember, unless it is almost time for your next dose – in that case, skip the missed dose and continue your regular schedule. Do not double the dose.
Can I buy Exforge HCT 5/160/12.5mg Tablet from DoctorOnCall?
Yes, Exforge HCT 5/160/12.5mg Tablet is available through DoctorOnCall, a licensed online pharmacy serving our Malaysian and Singaporean customers. As this is a prescription medicine, you will need to complete an online consultation so a doctor can assess your suitability and issue a valid prescription before the order is processed. This ensures the medicine is appropriate for your condition and used under proper medical supervision, whether you are ordering from Malaysia or Singapore.
Is the medication provided by DoctorOnCall genuine and safe to use?
DoctorOnCall sources its medicines through appropriate licensed pharmacy supply channels for our Malaysian and Singaporean customers. All orders are dispensed and checked by a registered pharmacist before delivery. Always use Exforge HCT 5/160/12.5mg Tablet according to your doctor’s instructions and the information provided with the product.
What payment methods does DoctorOnCall accept?
We accept payment via Online Banking, Credit Card, and e-Wallets (Boost, GrabPay) for our Malaysian and Singaporean customers, so you can choose whichever method is most convenient for you at checkout.
Does DoctorOnCall provide an installment payment plan for Exforge HCT 5/160/12.5mg Tablet?
DoctorOnCall provides an installment payment plan for eligible Malaysian and Singaporean customers, where applicable. Available plans, eligibility, and terms can vary by market, so please contact DoctorOnCall Customer Service for the latest information on installment options for your order.
Is delivery free, and how much does shipping for Exforge HCT 5/160/12.5mg Tablet cost?
Delivery charges may vary for our Malaysian and Singaporean customers depending on your delivery location and the applicable order terms at the time of purchase. For the most accurate and up-to-date delivery fee information, please contact DoctorOnCall Customer Service before placing your order.
How long does delivery take for Exforge HCT 5/160/12.5mg Tablet?
Our Malaysian customers can generally expect delivery within 3-5 working days, while our Singaporean customers generally receive their orders within 5-7 working days. These are expected timeframes rather than guarantees, and actual delivery time may vary depending on your delivery location, order processing time, courier operations, and whether the order falls on a weekend or public holiday.
What is DoctorOnCall’s shipping, return, or cancellation policy for Exforge HCT 5/160/12.5mg Tablet?
Shipping, return, and cancellation terms may vary for our Malaysian and Singaporean customers depending on the product and your order details. Please refer to DoctorOnCall’s Shipping & Delivery Policy and Return, Refund & Exchange Policy, or contact Customer Service, for the specific terms that apply to your order.
Ingredients / Active Ingredients
- Amlodipine / Valsartan / Hydrochlorothiazide 5/160/12.5mg
Safety Advice
Pregnancy
This medicine should be used cautiously during pregnancy. Monitoring may be required.
Breastfeeding
Use with caution. Monitor infant for potential adverse reactions.
Kidney
Generally safe, but caution may be required in some patients.
Liver
Use cautiously. Liver function monitoring may be required.
Alcohol
It is not advisable to consume alcohol while taking this medicine.
Driving
Use caution while driving until you know how this medicine affects you.
Medical Review
